耳蜗蛋白cochlin-tomoprotein在外淋巴瘘诊断中的应用  

The diagnostic value of cochlin-tomoprotein in perilymphatic fistula

作　　者：熊潇 于进涛 孙宇[1] XIONG Xiao;YU Jintao;SUN Yu

机构地区：[1]华中科技大学同济医学院附属协和医院耳鼻咽喉科,武汉430022

出　　处：《临床耳鼻咽喉头颈外科杂志》2020年第9期857-861,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金面上项目(No:81771003、81570923)。

摘　　要：由于各种原因引起外淋巴和中耳腔之间的骨质破损,或膜性组织和(或)韧带破裂,致使外淋巴和中耳腔交通,称为外淋巴瘘(perilymph fistula,PLF)。临床上确诊PLF的方法是经手术探查,显微镜或耳内镜下确认中耳和内耳之间存在瘘孔,瘘孔可位于圆窗或椭圆窗、骨折的骨迷路和异常的镫骨足板,可发生于头部外伤或气压伤、慢性中耳炎或特发性迷路窗膜破裂。Perilymphatic fistula(PLF)is defined as an abnormal communication between the fluid(perilymph)-filled space of the inner ear and the air-filled space of the middle ear and mastoid,or cranial spaces.At present the diagnostic criteria for perilymphatic fistula is the fistula hole confirmed by the microscope and endoscope between the middle ear and inner ear,the hole is located in the round or oval window,fractured bony labyrinth,microfissures,anomalous footplate,and can occur after head trauma or barotrauma,chronic inflammation,or in otic capsule dehiscence.Recently,the cochlin-tomoprotein(CTP)detected from the middle ear.CTP,the shortest isoform of cochlin encoded by the COCH gene,has been proven to be a perilymph-specific protein which is not expressed in blood,cerebrospinal fluid and saliva but is highly expressed in lymphatic fluid of the inner ear and is used as a diagnostic biochemical marker for perilymph fistula.The CTP test based on ELISA was performed on the lavage fluid of patients with suspected perilymph fistula to obtain comparatively accurate test results.This paper reviewed the diagnostic value of CTP in perilymphatic fistula.

关 键 词：外淋巴瘘 耳蜗蛋白 淋巴液 

分 类 号：R551.2[医药卫生—血液循环系统疾病]