三种畸形精子症的辅助生殖治疗结局探讨  

Outcomes of assisted reproductive technology for patients with different types of teratozoospermia

作　　者：李婵娟 张静静[1,2,3] 查晓敏 谈箐 吴娟 章志国[1,2,3] 朱复希 LI Chan-juan;ZHANG Jing-jing;ZHA Xiao-min;TAN Qing;WU Juan;ZHANG Zhi-guo;ZHU Fu-xi(Center of Reproductive Medicine,Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University;Key Laboratory of National Health Commission for Researches on Abnormal Gametes and Re-productive Tract;Key Laboratory of Anhui Province for Reproductive Health and Genetics,Anhui Medical Universi-ty,Hefei,Anhui 230022,China)

机构地区：[1]安徽医科大学第一附属医院妇产科生殖医学中心 [2]国家卫生健康委配子及生殖道异常研究重点实验室 [3]安徽医科大学生殖健康与遗传安徽省重点实验室,安徽合肥230022

出　　处：《中华男科学杂志》2020年第8期700-707,共8页National Journal of Andrology

基　　金：国家自然科学基金(81401251);安徽省高校优秀青年人才支持计划重点项目(gxyqZD2016050);安徽省转化医学研究院科研基金项目(2017zhyx29)。

摘　　要：目的:探讨圆头精子症、无头精子症和小顶体伴不规则头精子症患者的ICSI治疗结局,为临床辅助生殖治疗方案提供依据。方法:回顾性分析圆头精子症患者3例,无头精子症患者3例和小顶体伴不规则头精子症2例行ICSI治疗的临床治疗资料,分析其受精、卵裂、囊胚形成、着床率、临床妊娠率和活产率。结果:圆头精子症患者和无头精子症患者获得临床妊娠并出生健康后代,小顶体伴不规则头精子症患者受精率差,未获得临床妊娠。结论:圆头精子症和无头精子症行ICSI均能成功妊娠,小顶体伴不规则头精子症行ICSI尚未获得满意的临床治疗结局,但需增加样本量以待进一步证实。Objective: To discuss the outcomes of ICSI in infertile patients with globozoospermia(GS), acephalic spermatozoa syndrome(ASS) or teratozoospermia with miniacrosome and irregular-headed sperm defect(TMRHS). Methods: This retrospective study included 3 cases of GS, 3 cases of ASS and 2 cases of TMRHS undergoing ICSI. We analyzed the rates of fertilization, cleavage, blastocyst formation, implantation, clinical pregnancy and live birth in the three groups of patients. Results: The patients of the GS and ASS groups all achieved clinical pregnancies and healthy births, but those of the TMRHS group showed a lower fertilization rate than the other two groups and achieved no clinical pregnancy. Conclusion: ICSI could achieve successful clinical pregnancy in infertile patients with globozoospermia or acephalic spermatozoa syndrome, but no satisfactory clinical outcome in those with miniacrosome and irregular-headed sperm defect, though it has to be further proved by more studies with larger-sized samples.

关 键 词：畸形精子症 圆头精子症 无头精子症 小顶体 辅助生殖技术 

分 类 号：R698.2[医药卫生—泌尿科学]