红细胞血型OK抗原研究进展  

Advances in research on erythrocyte blood group OK antigen

作　　者：汪小葛[1] 李树中(审校)[1] 李中华 李凌波 田丰 WANG Xiaoge;LI Shuzhong;LI Zhonghua

机构地区：[1]江苏大学附属昆山医院,江苏昆山215300 [2]黑龙江省牡丹江市第二人民医院 [3]长春博讯生物技术有限责任公司 [4]江苏省昆山市第三人民医院

出　　处：《临床血液学杂志（输血与检验）》2020年第5期729-732,共4页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：1979年在一名日本妇女的血浆中发现了抗Oka,从而确认了OK抗原的存在。1998年国际输血协会(ISBT)确认OK抗原是独立的系统抗原,系统编码024,到2019年确认该系统有3个抗原,分别是:Oka、OKGV、OKVM,3个抗原都是高频抗原。近几年来OK血型抗原在遗传学、分子生物学等方面的研究都有了很大的进展,笔者整理了过去一些不明了的理论问题,并阐述了一些新的概念,本文就最近几年来的一些研究报道,做一简要综述。OK blood group antigen is the erythrocyte system antigen,which has three antigens.The OK antigen gene has 9 exons,and the encoding translation product is OK antigen glycoprotein,which is also a membrane differentiation antigen(CD147)and a transmembrane transporter involved in human lactate and pyruvate transport metabolism,which is one of the biochemical metabolic mechanisms of the human body.OK antigen is also a member of the immunoglobulin superfamily(IgSF),which involves in the human immune mechanism and cellular immune signaling.OK antigen is a tumor-related factor,which is directly related to tumor cells and interstitial invasion,infiltration and angiogenesis.

关 键 词：OK血型抗原 9个外显子 CD147 免疫信号传导 肿瘤相关因子 细胞生成素调控 跨膜转运蛋白 

分 类 号：R457.1[医药卫生—治疗学]