自体血回收在儿童非复杂性先天性心脏病手术中的应用:一项回顾性研究  

Application of autologous blood transfusion on surgery of uncomplex congenital heart disease in children:a retrospective study

作　　者：李上莹莹 杨飞[1] 崔洁[1] 叶茂[1,2] 涂生芬 Li Shangyingying;Yang Fei;Cui Jie;Ye Mao;Tu Shengfen(Department of Anesthesiology,Children’s Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,National Clinical Research Center for Child Health and Disorders,China International Science and Technology Cooperation Base of Child Development and Critical Disorders;Chongqing Key Laboratory of Pediatrics)

机构地区：[1]重庆医科大学附属儿童医院麻醉科、儿童发育疾病研究教育部重点实验室、国家儿童健康与疾病临床医学研究中心、儿童发育重大疾病国家国际科技合作基地,重庆400014 [2]儿科学重庆市重点实验室,重庆400014

出　　处：《重庆医科大学学报》2020年第10期1438-1441,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:31200853);国家临床重点专科建设资助项目(编号:国卫办医函〔2013〕544);重庆市自然科学基金资助项目(编号:cstc2012jjA10036);重庆市卫健委高端人才资助项目(编号:2015HBRC007)。

摘　　要：目的:探讨儿童非复杂性先天性心脏病手术中使用自体血回收是否可以减少临床用血。方法:选取重庆医科大学附属儿童医院2019年1月至2019年6月行手术治疗的非复杂性先天性心脏病患儿110例为研究对象,将其分为2组,使用自体血回收的患儿为病例组(38例),未使用自体血回收的患儿为对照组(72例)。统计分析2组患儿术中及术后临床用血情况。结果:与对照组比较,病例组患儿术中和术后输注血制品例数明显减少(P=0.019,P=0.000);病例组术中输注异体红细胞(red blood cell,RBC)量和新鲜冰冻血浆量明显减少(P=0.006,P=0.016);病例组患儿术后输注异体RBC量较对照组明显减少(P=0.001);病例组患儿术后血红蛋白(hemoglobin,Hb)量和红细胞压积(hematocrit,Hct)均较对照组高(P=0.001,P=0.010)。结论:对于需行手术治疗的非复杂性先天性心脏病患儿,术中使用自体血回收可以明显减少术中及术后用血,值得在临床推广。Objective:To investigate the application of autologous blood transfusion on surgery of uncomplex congenital heart disease in children for decreasing the need for clinical blood transfusion. Methods:A total of 110 patients with uncomplex congenital heart disease who underwent surgical treatment in our hospital from January 2019 to June 2019 were selected and divided into two groups:38 patients used autologous blood transfusion as the case group and 72 patients not used autologous blood transfusion as the control group. The number of intra-and-post-operation blood transfusions was collected and analyzed in two groups. Results:Compared with the control group,the number of intra-and-post-operation blood transfusions in the case group was significantly reduced(P=0.019,P=0.000);the number of allogeneic red blood cell(RBC)and fresh frozen plasma transfusions during operation in the case group were significantly reduced(P=0.006,P=0.016);the number of allogeneic RBC transfusion after surgery in the case group was significantly reduced(P=0.001);levels of hemoglobin(Hb)and hematocrit(Hct)after surgery in the case group were higher(P=0.001,P=0.010).Conclusion:The use of autologous blood transfusion during the operation can significantly reduce intraoperative and postoperative allogeneic blood transfusions in the children with uncomplex congenital heart disease requiring surgical treatment,which is worth clinical promotion.

关 键 词：儿童 先天性心脏病 自体血回收 

分 类 号：R654[医药卫生—外科学] R457.1[医药卫生—临床医学]