高原地区不同年龄人群血细胞参数的分层与对比研究  

Stratification and comparison of blood cell parameters of different age groups in plateau area

作　　者：李熙建[1] 谭扬 谭同均[1] 彭宇生[1] Li Xijian;Tan Yang;Tan Tongjun;Peng Yusheng(Department of Clinical Laboratory,The First People’s Hospital of Yibin)

机构地区：[1]宜宾市第一人民医院检验科,宜宾644000

出　　处：《重庆医科大学学报》2020年第10期1491-1496,共6页Journal of Chongqing Medical University

摘　　要：目的:探讨高原藏族人群几个血细胞参数随年龄变化和男女之间在不同年龄段的差异,为藏族人群和援藏人员的健康提供精准医学数据。方法:回顾性分析四川省甘孜藏族自治州2 550名高原藏族健康体检人员,并与宜宾市4 596名平原汉族人员进行对比。分析的血细胞参数有红细胞计数(red blood cell count,RBC)、血红蛋白(hemoglobin,Hgb)、红细胞压积(hematocrit,Hct)、红细胞分布宽度标准差(red blood cell distribution width-SD,RDW-SD)、红细胞分布宽度变异系数(red blood cell distribution width-CV,RDW-CV)、平均血小板体积(mean platelet volume,MPV)。按年龄将人群分成5组,A组≤10岁,10岁50岁,从每组人群总的状况,不同组间、不同性别人员和同一组内不同性别之间,以及相邻组别之间,分别进行比较与统计学分析。结果:在30岁以前,高原藏族男性RBC、Hgb、Hct上升比平原汉族明显;高原藏族女性在30岁以后,RBC、Hgb、Hct呈逐渐上升趋势,而平原汉族女性在30岁以后,RBC、Hgb、Hct却呈逐渐下降趋势,差异具有统计学意义(P<0.01)。在高原藏族各分组与总样本的比较中,RBC均有明显的统计学意义(P<0.01),Hgb在B、D、E组中,Hct、MPV在D、E组中差异有统计学意义(P<0.01);在高原藏族不同性别间的比较中,RBC、Hgb、Hct、RDW-CV在B、C、D、E组中均有明显的统计学差异(P<0.01);从具体数值波动与差别看,男性与女性的差别,以RBC、Hgb、Hct在C、D组中尤为明显。在高原藏族与平原汉族的分组分析中,Hgb、Hct在A组(≤10岁)中差异无统计学意义(P>0.01)。结论:高原藏族人群在RBC、Hgb、Hct、RDW-SD、RDW-CV、MPV几个血细胞参数上,因年龄不同和性别差异变化明显,部分参数的变化有统计学意义;和平原汉族相比差异具有统计学意义。了解这些差异变化,对高原藏族人群和当前大量援藏人员在疾病诊治和健康保障上,都是积极有益的。Objective:To investigate the changes of blood cell parameters with age and the differences between men and women at different ages of Tibetan people on the plateau,and to provide precise medical data for the health of Tibetan people and Tibetan aid cadres. Methods:This paper retrospectively studied 2 550 health examiners in Ganzi Tibetan Autonomous Prefecture of Sichuan Province and compared them with 4 596 low-altitude Han nationality examiners in Yibin. The blood cell parameters were red blood cell count(RBC),hemoglobin(Hgb),hematocrit(Hct),red blood cell distribution width-standard deviation(RDW-SD),red blood cell distribution width-variation coefficient(RDW-CV)and mean platelet volume(MPV). People were divided into 5 groups according to age,A≤10 years old,1050 years old. Comparisons and statistical analyses were made from the general condition of each group,between people in different groups,between different genders of people in the same group,and between people in adjacent groups. Results:We found that before the age of 30,the increase of RBC,Hgb,Hct in Plateau Tibetan males was more obvious than that in plain Han males. After the age of 30,the increase of RBC,Hgb and Hct in Plateau Tibetan women was a gradual trend while those of Han nationality in the plain were declining,with statistical significance(P<0.01). In the comparison of each group of the Tibetan plateau with the total sample,RBC had obvious statistical significance(P<0.01),Hgb in groups B,D,and E,and Hct and MPV in groups D and E showed significant differences(P <0.01). In the comparison between different genders of Tibetan plateau,RBC,Hgb,Hct,RDW-CV had significant statistical differences in groups B,C,D,E(P<0.01);from the specific value fluctuation and difference,the difference between males and females,RBC,Hgb,and Hct were particularly obvious in groups C and D. In the grouping analysis of plateau Tibetans and plain Hans,there was no significant difference in Hgb and Hct in group A(≤10 years old)(P>0.01). Conclusion:The parameters of RBC

关 键 词：精准医学 高原地区 藏族 血细胞计数 急性高原反应 年龄分组 性别差异 

分 类 号：R446.113[医药卫生—诊断学]