中药治疗卵巢癌的作用机制研究现状  

Overview of mechanism of traditional Chinese medicine treating ovarian cancer

作　　者：李梦皎 夏雷[2,3] Li Mengjiao;Xia Lei(Master Degree Student of Grade 2017,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Pathology,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Co-Innovation Center of Classic Traditional Chinese Medicine Formula of Shandong Province,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学,济南250355 [2]山东中医药大学病理教研室,济南250355 [3]山东中医药大学山东省中医经典名方协同创新中心,济南250355

出　　处：《国际中医中药杂志》2020年第5期501-503,共3页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81703839)。

摘　　要：综述中药治疗卵巢癌的作用机制研究相关文献,发现中药可通过线粒体途径、死亡受体途径、内质网应激途径诱导卵巢癌细胞凋亡,还可调节免疫、抗化疗药物耐药。中药在抗肿瘤治疗中,具有治疗靶点多、治疗阻力小、疗效确切、副作用少、成本低的优点。可通过建立有效的实验标准和评价标准,利用体内、外实验研究,推动对中药治疗机制的认识。The literature review on the treatment mechanism of traditional Chinese medicine(TCM)to ovarian cancer reveals that TCM can not only induce the apoptosis of ovarian cancer cell by three ways,namely mitochondrial pathway,death-receptor pathway,ER stress pathway,but also regulate body immunity and drug-tolerance of chemotherapeutics.The advantages of TCM treatment on tumor include relatively more therapeutic targets,less treating resistance,better medicine effect,less side effects,and lower cost.Through the elaborately designed experimental and assessment criteria,the TCM treatment mechanism can be recognized by in vivo and in vitro study.

关 键 词：药理作用分子作用机制(中药) 卵巢癌 细胞凋亡 综述 

分 类 号：R28[医药卫生—中药学]