辣椒素受体在心肌缺血/再灌注损伤中保护作用的研究进展  

Research advances on the protective effect of capsaicin receptor in myocardial ischemia/reperfusion injury

作　　者：吴利宁 陆姚[2] 余骏马[1] Wu Lining;Lu Yao;Yu Junma(Department of Anesthesiology,the Third Affiliated Hospital of Anhui Medical University,the First People's Hospital of Hefei,Hefei 230061,China;Department of Anesthesiology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第三附属医院,合肥市第一人民医院麻醉科,230061 [2]安徽医科大学第一附属医院麻醉科,合肥230022

出　　处：《国际麻醉学与复苏杂志》2020年第10期1017-1020,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(81770295)。

摘　　要：瞬时感受器电位香草酸受体1(transient receptor potential vanilloid 1,TRPV1)又称辣椒素受体或香草样受体1,它是瞬时受体电位蛋白组的一个亚家族,在多种脏器缺血/再灌注(ischemia/reperfusion,I/R)诱导的损伤中起着关键作用。在心肌I/R的过程中(离体或在体模型中),TRPV1通道在各种条件因素下被激活后,可以通过一系列的信号级联机制增加降钙素基因相关肽(calcitonin gene related peptide,CGRP)和P物质(substance P,SP)的释放,从而减轻心肌损伤。文章从糖尿病鼠、预处理和后处理以及参与的信号级联机制几方面来综述TRPV1通道在心肌I/R损伤中的心肌保护作用,以期未来更合理地将TRPV1这一靶点在临床上应用于心肌缺血患者。Transient receptor potential vanilloid 1(TRPV1),also known as capsaicin receptor or vanilla-like receptor 1,is a subfamily of transient receptor potential proteome,which plays a pivotal role in the injury induced by ischemia/reperfusion(I/R)in multiple organs.During myocardial I/R(in vitro or in vivo model),TRPV1 channel can be activated by various factors to increase the release of calcitonin gene related peptide(CGRP)and substance P(SP)through a series of signaling cascades,so as to alleviate myocardial injury.This article will review the protective effects of TRPV1 channel on myocardial I/R injury through the aspects of diabetic rats,preconditioning and postconditioning,and the signaling cascade mechanism involved,in order to rational use of TRPV1 as a target in patients with myocardial ischemia.

关 键 词：瞬时感受器电位香草酸受体1 缺血/再灌注损伤 心肌 

分 类 号：R587.2[医药卫生—内分泌] R542.2[医药卫生—内科学]