微小RNA-140与Notch信号通路及骨关节炎关系的研究进展  

Research progress on the relationship between micro RNA-140 and notch signaling pathway and osteoarthritis

作　　者：梁晓南[1] 肖渊铭 蓝翔 Liang Xiaonan;Xiao Yuanming;Lan Xiang(Department of Orthopedic Trauma and Hand Surgery,The First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi,530021,China)

机构地区：[1]广西医科大学第一附属医院创伤骨科手外科,广西南宁530021

出　　处：《当代医学》2020年第33期1-3,共3页Contemporary Medicine

基　　金：广西高校中青年教师基础能力提升项目(2017KY0126);广西自然科学基金(2019GXNSFAA245072);广西科技基地和人才专项(桂科AD17129012)。

摘　　要：骨关节炎是一种以骨质增生,关节软骨破坏、变性为主要病理改变的退行性疾病,但是目前发病机制尚不明确。微小RNA-140(miR-140)在软骨细胞中选择性高表达,可参与软骨细胞的形成、增殖、分化及凋亡的调控,因此,miR-140在阻断早期骨性关节炎发展方面具有重要作用。但是,RNA-140作用机制复杂,其参与骨性关节炎软骨退行性变的分子机制目前尚不明确。本研究针对RNA-140在软骨形成、软骨稳态维持、Notch信号通路及OA早期诊断方面进展进行综述。Osteoarthritis(OA)is a degenerative diseases mainly in articular cartilage,but its pathogenesis has not been elucidated.MiR-140 is specifically expressed in cartilage.More and more evidence demonstrated that miR-140 plays important roles in the molecular mechanisms in chondrogenic differentiation,proliferation,nature as well as apoptosis.So the regulation of the differentiation of cartilage plays a crucial role in blocking development of OA.Thus,the research on the miR-140 will reviewed recent literatures in order to discuss the role of miR-140 in chondrogenesis,cartilage homeostasis and Notch signal path as well as early diagnosis the Osteoarthritis.

关 键 词：微小RNA 骨性关节炎 软骨细胞 NOTCH信号通路 

分 类 号：R684.3[医药卫生—骨科学]