酪酸梭菌活菌片联合琥珀酸亚铁片治疗儿童缺铁性贫血的疗效观察  

Efficacy of Clostridium butyricum tablets combined with ferrous succinate tablets in the treatment of children with iron deficiency anemia

作　　者：钱慧莉[1] 赵娜 焦朝艳 QIAN Hui-li;ZHAO Na;JIAO Chao-yan(Department of Paediatrics, Central Hospital of Cangzhou,Hebei Province, Cangzhou 061001, China)

机构地区：[1]河北省沧州市中心医院儿内二科,河北沧州061001

出　　处：《河北医科大学学报》2020年第11期1317-1320,共4页Journal of Hebei Medical University

摘　　要：目的观察酪酸梭菌活菌片联合琥珀酸亚铁片治疗缺铁性贫血的临床疗效及贫血并发症发生情况。方法选择缺铁性贫血患儿81例,随机分为治疗组40例和对照组41例。对照组给予琥珀酸亚铁片治疗,治疗组采用酪酸梭菌活菌片联合琥珀酸亚铁片治疗。比较2组红细胞压积、血色素、血清铁及血清铁蛋白贫血指标,比较2组恶心、呕吐、食欲不振、腹泻、便秘不良反应发生情况,比较2组临床疗效。结果治疗后,2组红细胞压积、血红蛋白、血清铁及血清铁蛋白水平均高于治疗前,治疗组血细胞比容、血红蛋白、血清铁及铁蛋白水平高于对照组,差异有统计学意义(P<0.05)。治疗组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。2组总有效率差异无统计学意义(P>0.05)。结论酪酸梭菌活菌片联合琥珀酸亚铁片治疗缺铁性贫血疗效优于琥珀酸亚铁片单药治疗,可明显降低不良反应发生率,具有较好的临床使用价值。Objective To observe the clinical efficacy of clostridium butyricum tablets combine with ferrous succinate tablets treatment on iron deficiency anemia and the incidence of anemia complications.Methods Eighty-one children with iron deficiency anemia were selected and randomly divided into treatment group(40 cases)and control group(41 cases).The control group was given ferrous succinate tablets,and the treatment group was treated with clostridium butyricum tablets combined with ferrous succinate tablets.Hematocrit,hemoglobin,serum iron and serum ferritin anemia were compared between two groups,and the adverse reactions of nausea,vomiting,anorexia,diarrhea and constipation were compared between two groups,and the clinical efficacy was compared between two groups.Results After treatment,hematocrit,hemoglobin,serum iron and serum ferritin levels of the two groups were higher than those before treatment,hematocrit,hemoglobin,serum iron and ferritin levels in the treatment group were higher than those in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the treatment group was lower than that in the control group(P<0.05).There was no significant difference in the total effective rate between two groups(P>0.05).Conclusion The efficacy of clostridium butyricum tablets combined with ferrous succinate tablets in the treatment of iron deficiency anemia is better than that of ferrous succinate tablets monotherapy.It can significantly reduce the incidence of adverse reactions and has good clinical use value.

关 键 词：血 缺铁性 酪酸梭菌 琥珀酸亚铁 儿童 

分 类 号：R725.563[医药卫生—儿科]