湖南省腹水型晚期血吸虫病合并乙型肝炎患者抗病毒治疗现状分析  

Analysis on the antiviral treatment of advanced schistosomiasis with ascites and hepatitis B,Hunan Province

作　　者：王洪波[1] 荆群山[1] 郑娜[1] 陶江 谢韵[1] 彭妮娜[1] WANG Hong-bo;JING Qun-shan;ZHENG Na;TAO Jiang;XIE Yun;PENG Ni-na(Hunan Provicial Institute of Schistosomiasis Control,National Key Clinical Specialty,WHO Collaborating Center on Schistosomiasis Control in Lake Regions,Hunan Key Laboratory of Immunology and Transmission Control of Schistosomiasis,Yueyang 41400,China)

机构地区：[1]湖南省血吸虫病防治所,国家血吸虫病临床重点专科,WHO湖区血吸虫病防治合作中心,血吸虫病免疫与传播控制湖南省重点实验室,岳阳414000

出　　处：《热带病与寄生虫学》2020年第4期231-233,共3页Journal of Tropical Diseases and Parasitology

基　　金：国家血吸虫病临床重点专科建设项目(卫办医政函〔2012〕649)。

摘　　要：目的了解湖南省腹水型晚期血吸虫病合并乙型肝炎患者的抗病毒治疗现状,进一步规范治疗。方法对湖南省血吸虫病防治所湘岳医院国家血吸虫病临床重点专科2018年全年收治的117例腹水型晚期血吸虫病合并乙型肝炎患者的临床资料进行回顾性分析,并进行随访观察。结果117例腹水型晚期血吸虫病合并乙型肝炎患者中,男性85例,女性32例;年龄33~86岁,平均年龄(53.99±11.46)岁。进行抗病毒治疗人数71例,占比60.7%;48例选用阿德福韦酯,44例获得病毒学应答,2例出现耐药,另有2例因上消化道出血死亡;23例使用恩替卡韦,均获得病毒学应答。有46例患者未进行抗病毒治疗,主要由于经济压力以及治疗时间长。结论腹水型晚期血吸虫病合并乙型肝炎的比例较高,应进一步规范化抗乙肝病毒治疗。Objective To understand the current situation of antiviral treatment of advanced schistosomiasis patients with ascites and hepatitis B for further standardizing the clinical treatment protocol.Methods The clinical data were retrospectively analyzed in 117 patients of advanced schistosomiasis with ascites concomitant with hepatitis B,admitted to and treated in 2018 in the National Key Clinical Specialty of Schistosomiasis of Xiangyue Hospital affiliated to Hunan Provincial Institute of Schistosomiasis Control.All patients were followed up.Results Of the 117 cases of advanced schistosomiasis with hepatitis B,85 were males and 32 females.The patients aged from 33 to 86 years old,with an average of(53.99±11.46)years.Seventy-one(60.7%)received antiviral therapy,in whom 48 were treated with adefovir dipivoxil and 44 with virological response.Drug resistance occurred in 2 patients,and death occurred in another 2 from upper gastrointestinal hemorrhage.Virological response was achieved in the 23 patients treated by entecavir.Forty-six patients did not receive antiviral treatment due to economic reasons and failure of compliance with long-term treatment course.Conclusion The proportion of advanced schistosomiasis with ascites and hepatitis B is high,and standardized anti-hepatitis B treatment should be strengthened.

关 键 词：晚期血吸虫病 腹水 乙型肝炎 抗病毒治疗 

分 类 号：R532.21[医药卫生—内科学] R512.62[医药卫生—临床医学]