六叶龙胆化学成分研究  

Chemical Constituents from Gentiana hexaphylla Maxim.ex Kusnez.

作　　者：刘越[1,3,4] 孙晓 杨瑞瑞[3] 郭耀武 马双成 LIU Yue;SUN Xiao;YANG Rui-rui;GUO Yao-wu;MA Shuang-cheng(School of Chinese Materia Medi ca,Bejing University of Chinese Medicine,Bejing 102488,China;Xi'an Institute for Food and Drug Control,Xi'an 710054,Chi na;Shaanxi Institute for Food and Drug Control,Xi'an 710065,China;National Institutes for Food and Drug Control,Bejing 100050,China)

机构地区：[1]北京中医药大学,北京102488 [2]西安市食品药品检验所,西安710054 [3]陕西省食品药品监督检验研究院,西安710065 [4]中国食品药品检定研究院,北京100050

出　　处：《中国药学杂志》2020年第21期1780-1786,共7页Chinese Pharmaceutical Journal

基　　金：国家重大新药创制专项课题资助(2018ZX09735-006)。

摘　　要：目的研究六叶龙胆化学成分。方法采用硅胶柱色谱、Sephadex LH-20葡聚糖凝胶柱色谱、制备液相色谱等色谱技术进行分离和纯化,通过理化方法和波谱数据分析鉴定化合物的结构。结果从六叶龙胆中分离鉴定了17个化合物,分别为:龙胆苦苷(1),獐牙菜苷(2),獐牙菜苦苷(3),三叶草苷(4),rindoside(5),rigenolides G(6),poacynose(7),vanillyl alcohol-4-O-β-D-glucopyranoside(8),isotachioside(9),tachioside(10),1,5-bis (β-D-glucopyranosyloxy-2-(3′,3′-dimethylallyl) benzene(11),松柏苷(12),5,7,3′,4′-四羟基-8-C-β-D-葡萄糖黄酮碳苷(13),牡荆素(14),丁香树脂酚葡萄糖苷(15),松脂酚-4-O-β-D吡喃葡萄糖苷(16)和腺苷(17)。其中化合物1~6为裂环环烯醚萜苷类成分,化合物7~12为苯基糖苷类衍生物,化合物13~14为黄酮类成分,化合物15~16为木脂素类成分。结论化合物1~17均为首次从该植物中分离得到。OBJECTIVE To investigate the chemical components from Gentiana hexaphylla. METHODS The compounds were isolated by column chromatography with silica gel, Sephadex LH-20 and preparative HPLC. The structures were elucidated by the means of spectral data analysis. RESULTS Seventeen compounds were isolated, and their structures were determined as gentiopicroside(1), sweroside(2), swertiamarin(3), trifloroside(4), rindoside(5), rigenolides G(6), poacynose(7), vanillyl alcohol-4-O-β-D-glucopyranoside(8), isotachioside(9), tachioside(10), 1,5-bis(β-D-glucopyran osyloxy-2-(3′, 3′-dimethylallyl) benzene(11), coniferin(12), 5, 7, 3′, 4′-tetrahydroxy-8-C-β-D-glucopyranosyl flavone(13), vitexin(14), syringaresinol-4′-O-β-D-glucopy ranoside(15), pinoresinol-4-O-β-D-glucopyranoside(16), and adenosine(17). CONCLUSION Compounds 1-17 are isolated from this plant for the first time.

关 键 词：六叶龙胆 裂环环烯醚萜苷 苯基糖苷衍生物 黄酮 木脂素 

分 类 号：R284[医药卫生—中药学]