慢性宫颈炎并发HPV感染者Th1/Th2细胞因子变化及微波疗效分析  

Changes of Th1/Th2 cytokines in patients with chronic cervicitis complicated with HPV infection and analysis of the effect of microwave treatment

作　　者：潘倩雄 叶晓智 杨丽红 冯维良[1] 丁蓉 PAN Qian-xiong;YE Xiao-zhi;YANG Li-hong;FENG Wei-liang;DING Rong(不详;Ruian Peoples Hospital,Ruian,Zhejiang 325200,China)

机构地区：[1]瑞安市人民医院妇幼分院检验科,浙江瑞安325200 [2]医疗服务集团塘下第一分院妇产科,浙江瑞安325204 [3]浙江省杭州迪安医学检验中心,浙江杭州310030 [4]瑞安市中医院皮肤科,浙江瑞安325200

出　　处：《中华医院感染学杂志》2020年第19期3016-3020,共5页Chinese Journal of Nosocomiology

基　　金：浙江省自然科学基金资助项目(2019374)。

摘　　要：目的慢性宫颈炎并发人乳头瘤病毒(Human papilloma virus,HPV)感染者Th1/Th2细胞因子改变及微波治疗效果分析。方法选择瑞安市人民医院妇幼分院妇产科2018年9月-2019年11月收治的慢性宫颈炎合并HPV感染患者74例为研究组,选取同期入院未合并HPV感染宫颈炎患者74例作为对照组。对不同糜烂面积、糜烂症状及两组治疗前后血清白细胞介素-12(Interleukin-12,IL-12)、干扰素-γ(Interferon-γ,IFN-γ)、IL-4、IL-8水平进行比较。结果两组患者随糜烂程度的增加,IL-12、IFN-γ水平不断减少,IL-4、IL-8水平不断增加,不同糜烂程度患者之间IL-12、IFN-γ、IL-4、IL-8水平总体差异有统计学意义(P<0.05);随着病变程度的增加,IL-12、IFN-γ水平不断减少,IL-4、IL-8水平不断增加,不同病变程度患者之间IL-12、IFN-γ、IL-4、IL-8水平总体差异有统计学意义(P<0.05);治疗前研究组IL-12、IFN-γ为(10.84±4.21)pg/ml、(148.42±34.45)pg/ml低于对照组,IL-4、IL-8为(35.35±14.21)pg/ml、(118.85±34.28)pg/ml高于对照组(P<0.05);治疗后,两组IL-12、IFN-γ水平均明显上升,IL-4、IL-8水平明显下降,差异具有统计学意义(P<0.05)。对照组患者治疗疗效优于研究组(P=0.033)。结论慢性宫颈炎合并HPV感染患者的Th1/Th2免疫失衡随疾病严重程度增加而加重,应加强HPV筛查并尽早开始治疗,防止疾病恶性进展。OBJECTIVE To analyze the changes of Th1/Th2 cytokines in patients with chronic cervicitis complicated by human papilloma virus(HPV) infection and the effect of microwave treatment. METHODS Totally 74 patients with chronic cervicitis and HPV infection who were admitted to the Department of Obstetrics and Gynecology of the Women and Children Branch of Ruian People’s Hospital from Sep. 2018 to Nov. 2019 were selected as the study group, and 74 patients without HPV cervicitis admitted at the same time were selected as the control group. The levels of serum IL-12, IFN-γ, IL-4 and IL-8 were compared in groups of different erosion areas and erosion symptoms, and before and after treatment in the two groups. RESULTS With the increase of the degree of erosion, the levels of IL-12 and IFN-γ continued to decrease, and the levels of IL-4 and IL-8 continued to increase. The overall difference of IL-12, IFN-γ, IL-4, and IL-8 level among patients with different degrees of erosion was significant(P<0.05). With the increase of the degree of disease, the levels of IL-12 and IFN-γ continued to decrease, and the levels of IL-4 and IL-8 continued to increase. The overall difference in levels of IL-12, IFN-γ, IL-4 and IL-8 were significant difference among patients with different disease levels(P<0.05). Before treatment, the levels of IL-12 and IFN-γ in the study group were(10.84±4.21)pg/ml and(148.42±34.45)pg/ml, respectively, significently lower than those in the control group, and the levels of IL-4 and IL-8 were(35.35±14.21)pg/ml and(118.85±34.28)pg/ml, respectively, significently higher than those in the control group(P<0.05). After treatment, the levels of IL-12 and IFN-γ in the two groups increased significantly, while the levels of IL-4 and IL-8 decreased significantly(P<0.05). The total effective rate of treatment of the control group was higher than that of the study group(P=0.033). CONCLUSION The Th1/Th2 immune imbalance in patients with chronic cervicitis complicated with HPV infection aggravated with the seve

关 键 词：慢性宫颈炎 人乳头瘤病毒 TH1/TH2 微波治疗 细胞因子 

分 类 号：R711.32[医药卫生—妇产科学]