Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K  

作　　者：Pengbao Lian Qiang Liu Lizhen Chen Cai Cao Jiaxiang Zhao Jianlong Wang 

机构地区：[1]School of Chemical Engineering and Technology,North University of China,Taiyuan 030051,China [2]Hubei Dongfang Chemical Industry Co.,Ltd,Xiangyang 441403,China

出　　处：《Chinese Journal of Chemical Engineering》2020年第10期2634-2639,共6页中国化学工程学报（英文版）

基　　金：supported by the Military Chemistry and Pyrotechnics National Defense Specialty Fund for North University of China。

摘　　要：In this paper,the solubility of 4-nitroimidazole in twelve pure solvents(toluene,benzene,1,4-dioxane,acetonitrile,ethyl acetate,acetone,GBL,ethanol,methanol,n-butanol,DMF and NMP)were determined by using the laser monitoring system from 278.15 K to 323.15 K under 101.1 k Pa,which are 0.00018–0.00070,0.00021–0.00073,0.00034–0.00092,0.00038–0.00142,0.00047–0.00120,0.00126–0.00303,0.00225–0.00517,0.00310–0.00724,0.00467–0.00982,0.00453–0.01940,0.01947–0.04652,and 0.04670–0.07452,respectively.At constant temperature,the mole fraction solubility of 4-nitroimidazole were increased as the following order:toluene<benzene<1,4-dioxane<(ethyl acetate or acetonitrile)<acetone<GBL<ethanol<(methanol or nbutanol)<DMF<NMP,and the solubility of 4-nitroimidazole in(ethyl acetate,acetonitrile)and(methanol,n-butanol)had an intersection point at 297.55 K and 281.85 K,respectively.The solubility of 4-nitroimidazole could be increased with increasing temperature in twelve pure solvents.The ideal model,modified Apelblat equation,polynomial empirical equation,andλh equation were used to correlate the experimental values.The experimental solubility values were employed to calculate the standard dissolution enthalpy,standard dissolution entropy and Gibbs energy.The dissolution of 4-nitroimidazole could be an endothermic process in twelve pure solvents.The determination and fitting solubility of 4-nitroimidazole have important guiding significance for the purification and crystallization of its preparation process.

关 键 词：4-Nitroimidazole Laser monitoring system Solid–liquid equilibrium Solubility model Thermodynamic properties 

分 类 号：O626.23[理学—有机化学] O645.12[理学—化学]