Seipin基因对动物脂肪储存调控作用的研究进展  

A Review of the Studies on the Regulation of Seipin Gene in Animal Fat Storage

作　　者：艾庆辉[1,2] 陈梦然 陈秋池 麦康森[1,2] AI Qing-Hui;CHEN Meng-Ran;CHEN Qiu-Chi;MAI Kang-Sen(The Key Laboratory of Aquaculture Nutrition and Feed of Ministry of Agriculture and Rural Affairs;The Key Laboratory of Mariculture of Ministry of Education,Ocean University of China,Qingdao 266003,China)

机构地区：[1]中国海洋大学农业部水产动物营养与饲料重点实验室,山东青岛266003 [2]中国海洋大学海水养殖教育部重点实验室,山东青岛266003

出　　处：《中国海洋大学学报（自然科学版）》2021年第1期17-22,共6页Periodical of Ocean University of China

基　　金：国家杰出青年科学基金项目(31525024);国家自然科学基金重点项目(31830103)资助。

摘　　要：脂肪组织是机体内储存脂肪的核心部位,其功能出现异常会导致生物体生理紊乱。近年来研究发现,Seipin在调控脂肪分化和脂滴(Lipid droplets,LDs)形成中发挥着重要作用,Seipin基因突变会导致严重的脂肪储存障碍。目前,Seipin调控动物脂肪储存的研究多在人类和小鼠等模型中开展,鱼类Seipin相关研究较少。本文介绍了Seipin基因的分布与结构,从脂肪分化和LDs形态两方面探讨了Seipin在脂质储存中的作用及调控机制,并提出了系统研究鱼类Seipin的必要性和开展鱼类Seipin机制研究的方向,旨在进一步理解Seipin调控脂肪储存的分子机理,为寻找脂肪异常沉积的缓解策略奠定基础。Adipose tissue is the primary place of fat storage,and its abnormal function can cause physiological disorders.In recent years,studies have found that seipin plays an important role in regulating adipoge-nesis and lipid droplets(LDs)formation.Seipin gene mutations can cause severe fat storage disorders.At present,the researches on the regulation of seipin in animal fat storage is mostly carried out in human and mouse models,and there is less research on seipin in fish species.Here we summarize recent advances in the distribution and structure of seipin,and discusses the role and regulatory mechanism of seipin in fat storage from the aspects of adipogenesis and LDs morphology.We propose the necessity of systematic research of seipin in fish species and the research direction of the mechanism.It aims to further understand the molecular mechanism of seipin in regulating fat storage,with a view to laying a foundation for finding mitigation strategies for abnormal lipid deposition.

关 键 词：Seipin 脂肪分化 脂滴形态 脂肪异常沉积 鱼类 

分 类 号：S917.4[农业科学—水产科学]