生长分化因子11对老年慢性心力衰竭患者的临床诊断及预后的相关性评价  

Relationship between Growth Differentiation Factor 11 and Clinical Diagnosis and Prognosis in Older Patients with Chronic Heart Failure

作　　者：张秀敬 谭化 李娜 师志芳[1] 贾营 郝哲[1] Zhang Xiujing;Tan Hua;Li Na;Shi Zhifang;Jia Ying;Hao Zhe(Division I of Cadre Health Care,the Third Hospital of Shijiazhuang,Shijiazhuang 050000,China;Division II of Cadre Health Care,the Third Hospital of Shijiazhuang,Shijiazhuang 050000,China)

机构地区：[1]河北省石家庄市第三医院干部保健一科,石家庄050000 [2]河北省石家庄市第三医院干部保健二科,石家庄050000

出　　处：《国际老年医学杂志》2020年第6期370-372,390,共4页International Journal of Geriatrics

基　　金：石家庄市科技局项目(171461913)。

摘　　要：目的探究生长分化因子11 (GDF11)在老年慢性心力衰竭临床诊断及预后的作用并对其临床意义进行综合评价。方法回顾性分析2017年1月~2017年12月河北省石家庄市第三医院住院老年患者135例,分为观察组90例,为慢性心力衰竭病史6个月以上老年患者;对照组45例,为其他系统疾病老年患者。比较两组治疗前、治疗1周后及治疗6个月后的心功能指标、血清GDF11与脑钠肽(BNP)水平。结果观察组治疗前、治疗1周及6个月后血清GDF11水平均显著高于对照组(P <0.05),在治疗1周及6个月时观察组患者血清GDF11均显著低于治疗前(P <0.05);观察组治疗前、治疗1周后血清BNP水平均显著高于对照组(P <0.05),治疗6个月后与对照组比较差异无统计学意义(P> 0.05),治疗1周及6个月后血清BNP水平显著低于治疗前(P <0.05);观察组治疗前、治疗1周后左室射血分数(LVEF)显著低于对照组(P <0.05),左室舒张末内径(LVEDD)显著高于对照组(P <0.05),治疗6个月后与对照组比较差异均无统计学意义(P> 0.05),观察组在治疗1周及6个月后,LVEF显著高于治疗前(P <0.05),LVEDD显著低于治疗前(P <0.05)。结论 GDF11可有效反映老年心力衰竭的疾病状态且其变化较缓慢,有利于对老年患者疾病进行长时程动态监测,可作为老年慢性心力衰竭的辅助检测指标应用于临床诊断中。Objective To explore the role of growth differentiation factor 11(GDF11)in the diagnosis and prognosis of chronic heart failure in older patients and to evaluate its clinical significance.Methods 135 older patients were collected from January 2016 to December 2016 in the Third Hospital of Shijiazhuang.The patients were divided into the observation group(90 patients with chronic heart failure for more than 6 months)and the control group(45 patients with other systemic diseases).The cardiac function,the levels of serum GDF11 and brain natriuretic peptide(BNP)were examined before treatment,after 1 week and 6 months of treatment.Results In the observation group,before treatment,after 1 week and 6 months of treatment,the level of GDF11 was significantly higher than that in the control group(P<0.05).In the observation group,after 1 week and 6 months of treatment,the level of GDF11 was significantly lower than that before treatment(P<0.05).In the observation group,before treatment and after 1 week of treatment,the level of BNP was significantly higher than that in the control group(P<0.05),while after 6 months of treatment,there was no significant difference in BNP level between the two groups(P>0.05).In the observation group,after 1 week and 6 months of treatment,the level of BNP was significantly lower than that before treatment(P<0.05).In the observation group,before treatment and after 1 week of treatment,left ventricular ejection fraction(LVEF)was lower(P<0.05)and left ventricular end diastolic diameter(LVEDD)was higher(P<0.05)than those in the control group,while after 6 months of treatment,there was no significant difference in LVEF and LVEDD between the two groups(P>0.05).In the observation group,after 1 week and 6 months of treatment,LVEF was higher,LVEDD was lower than that before treatment(P<0.05).Conclusion GDF11 could effectively reflect the state of older patients with heart failure due to its slowly change.It might be useful for long-term dynamic monitoring for the patients.It also could be used as an aux

关 键 词：生长分化因子11 脑钠肽 老年 慢性心力衰竭 诊断 

分 类 号：R541.6[医药卫生—心血管疾病]