动物低氧应激与线粒体功能机制  

Hypoxic Stress and Mitochondrial Function Mechanism in Animals

作　　者：陆逸 蔡杰 王迪铭[1] 刘建新[1] LU Yi;CAI Jie;WANG Diming;LIU Jianxin(Institute of Dairy Science,College of Animal Science,Zhejiang University,Hangzhou 310029,China)

机构地区：[1]浙江大学动物科学学院,奶业科学研究所,杭州310029

出　　处：《动物营养学报》2020年第11期5046-5052,共7页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金项目(31930107);国家现代农业产业技术体系(CARS-36)。

摘　　要：低氧是动物面临环境、疾病、代谢变化的重要应激源之一,可导致机体自由基稳衡态失衡,损伤细胞。线粒体是感应氧气变化、产生活性氧(ROS)的最重要的细胞器,通过控制其总量和改变能量代谢以适应低氧。低氧状态可激活低氧诱导因子-1(HIF-1)参与调控低氧补偿机制,降低ROS带来的细胞损害;同时线粒体生物合成增加,可能是线粒体抵御低氧应激、提高机体适应性的新策略。本文综述了动物低氧应激的分类,以及从细胞和分子水平讨论了低氧应激中HIF-1的适应性调节机制以及线粒体功能的变化。Hypoxia is one of the important stress sources that animals face with changes in environment,disease,and metabolism,which can lead to the imbalance of free radical homeostasis and damage to cells. Mitochondria are the most important organelles that sense changes in oxygen and produce reactive oxygen species(ROS),and adapt to hypoxia through mass control and changes in energy metabolism. Hypoxia can activate hypoxia-inducible factor-1(HIF-1)to participate in the regulation of hypoxia compensation mechanism and reduce cellular damage caused by reactive oxygen species. Meanwhile,the increase in mitochondrial biosynthesis may be a new strategy for mitochondria to resist against hypoxic stress and improve the adaptability of the body.This article reviewed the classification of hypoxic stress in animals and focused on the adaptive regulatory mechanism of HIF-1 and changes in mitochondrial function at the cellular and molecular levels.

关 键 词：低氧应激 HIF-1 线粒体 线粒体生物合成 

分 类 号：S811.2[农业科学—畜牧学]