黄芩黄酮抗衰老作用机制研究进展  

Research Progress on Anti-aging Mechanism of Flavonoids from Scutellaria Baicalensis

作　　者：史敏[1] 段峰[2] 李倩[1] 卫华[1] 孙琳(综述) 封兴华(审校) SHI Min;DUAN Feng;LI Qian;WEI Hua;SUN Lin;FENG Xing-hua(Xi’an Peihua University,Xi’an 710125,Shaanxi,China;Department of Dermatology,Armed Police Forces Corps Hospital of Henan Province,Zhengzhou 450000,Henan,China)

机构地区：[1]西安培华学院,陕西西安710125 [2]武警河南总队医院皮肤科,河南郑州450000

出　　处：《中国美容医学》2020年第11期174-178,共5页Chinese Journal of Aesthetic Medicine

基　　金：陕西省教育厅突发公共卫生安全专项科学研究计划项目(项目名称:黄芩素对小鼠急性肺炎的干预效果及其药理调节机制研究,编号:20JG023)。

摘　　要：衰老的发生是一个复杂的生物学过程,其发生机制与活性氧蓄积、端粒短缩、免疫功能低下、慢性炎症及神经内分泌失调有关。中药黄芩黄酮类活性成分黄芩苷、黄芩素及汉黄芩素等具有抗氧化、抗炎、免疫调节、抑制肿瘤端粒酶活性、改善神经内分泌等药理作用。本文基于现代衰老学说,对近年来报道的关于黄芩黄酮类化合物抗衰老相关药理作用及其机制研究进展做一综述,旨在为今后黄芩黄酮类化合物的抗衰老研究提供思路,为开发黄芩有效成分的抗衰老新药提供理论依据。The occurrence of aging is a complex biological process,its mechanism is related to the accumulation of reactive oxygen species,telomere shortening,Immunocompromised,chronic inflammation and neuroendocrine disorders.Scutellaria flavonoid active ingredients,such as baicalin,baicalein,wogonin,etc.have anti-oxidation,anti-inflammatory,immune regulation,inhibit tumor telomerase activity,improve neuroendocrine and other pharmacological effects.On the basis of modern aging theory,we reviewed the studys of the anti-aging-related pharmacological effects and mechanisms of flavonoids of Scutellaria baicalensis Georgi in recent years.The aim is to provide theoretical ideas for future anti-aging research on flavonoids of Scutellaria baicalensis Georgi,and provide a theoretical basis for the development of new anti-aging drugs with active ingredients of Scutellaria baicalensis Georgi.

关 键 词：抗衰老 黄芩 黄酮 衰老机制 

分 类 号：R339.38[医药卫生—人体生理学]