特异性免疫治疗支气管哮喘的机制及对肺功能的影响  

Mechanism of allergen specific immunotherapy and its influence on lung function in asthma children

作　　者：刘金玲[1] 林燕芬 詹雪琴 王颖硕[1] 陈志敏[1] Liu Jinling;Lin Yanfen;Zhan Xueqin;Wang Yingshuo;Chen Zhimin(Department of Respiration,Children's Hospital Affiliated to Zhejiang University School of Medicine,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属儿童医院呼吸科,杭州310000

出　　处：《中华实用儿科临床杂志》2020年第21期1610-1613,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：浙江省教育厅基金(Y201534178);浙江省自然科学基金(LY16H010001);浙江省卫生厅基金(2013RCA027)。

摘　　要：支气管哮喘(哮喘)是儿童一种常见的反复发作的慢性气道炎症性病变。目前临床上主要应用β2受体激动剂快速缓解症状及吸入糖皮质激素进行长期控制。变应原特异性免疫治疗(AIT)可以调整哮喘的自然病程,对控制哮喘症状、降低气道高反应、改善肺功能有一定疗效,是目前唯一针对病因的治疗方案。现就AIT治疗哮喘的机制及对肺功能的影响方面进行综述,为提高其临床疗效提供依据。Asthma is a common chronic airway inflammatory disease in children.Currently,symptomatic control can be achieved in the majority of patients through a combination of β2 receptor agonists for rapid relief of symptoms and inhaled corticosteroids for long-term control.As the only causal treatment modality at present,allergen-specific immunotherapy(AIT)may modify the natural course of asthma,and can control the symptoms,reduce airway hyperresponsiveness and improve lung function.In order to provide evidence for improving the effect of AIT on asthma,the mechanism of AIT in asthma and its effect on lung function were discussed in this paper.

关 键 词：特异性免疫治疗 哮喘 肺功能 儿童 

分 类 号：R725.6[医药卫生—儿科]