(R)-α-硫辛酸合成方法的研究进展  

Advances in Synthetic Methods of(R)-α-Lipoic Acid

作　　者：韩修 康传清[2] HAN Xiu;KANG Chuanqing(College of Chemistry,Sichuan University,Chengdu 610000,China;Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China)

机构地区：[1]四川大学化学学院,成都610064 [2]中国科学院长春应用化学研究所,高分子复合材料工程实验室,长春130022

出　　处：《应用化学》2020年第11期1236-1248,共13页Chinese Journal of Applied Chemistry

摘　　要：(R)-α-硫辛酸可用于预防和治疗糖尿病及相关并发症,也可以作为保健品使用,用途广泛,因而其高效合成方法长期以来受到广泛关注。目前,合成(R)-α-硫辛酸的方法主要有酶和化学方法催化的不对称合成、消旋体的手性拆分以及手性底物控制的不对称合成。本文将以此为分类标准,对目前所报道的(R)-α-硫辛酸合成方法进行总结归纳和展望。The methods for the effective synthesis of(R)-α-lipoic acid have been widely investigated since(R)-α-lipoic acid can be widely used for the treatment of diabetes and diabetic complications.It is also extensively used in health care products.Therefore,asymmetric synthesis of(R)-α-lipoic acid has attracted broad interests from the community of both academia and industry.To date,the reported routes for the synthesis of(R)-α-lipoic acid include asymmetric synthesis catalyzed by the enzymatic and chemical catalysts,chiral resolution,and chiral substrate-controlled synthesis.Based on this classification,this paper summarizes the advances of the methods for asymmetric synthesis of(R)-α-lipoic acid and predicts future prospects.

关 键 词：硫辛酸 手性拆分 不对称合成 

分 类 号：O629.9[理学—有机化学]