黄体酮纳米胶束构建及体外释放行为  

Preparation and Release Behavior of Progesterone Nano Micelles in Vitro

作　　者：齐延新 黄宇彬[2] 金宁一[1,3] QI Yanxin;HUANG Yubin;JIN Ningyi(Medical College,Yanbian University,Yanji,Jilin 133002,China;State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;Institute of Military Veterinary Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Changchun 130112,China)

机构地区：[1]延边大学医学院,吉林延吉133002 [2]中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春130022 [3]军事科学院军事医学研究院,军事兽医研究所,长春130122

出　　处：《应用化学》2020年第11期1340-1342,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(51673188,51903233,21975246)项目资助。

摘　　要：为了制备可缓释释放的黄体酮纳米胶束新剂型,构建了两嵌段聚合物载体聚乙二醇-聚丙烯基缩水甘油醚(PEG-PAGE),组装成胶束,对黄体酮担载,考察不同条件下的载药量和包封率,筛选出最佳比例,并进行体外释放研究。结果表明,该胶束能够担载黄体酮,载药量为4.26%,包封率为21.30%,48 h内累计释放达61.31%,能够有效地延缓黄体酮的释放,为黄体酮纳米剂型的开发提供了实验和技术参考。To prepare new controlled-release progesterone nano micelles,polyethylene glycol-polypropylene glycidyl ether polymer(PEG-PAGE),a diblock degradable polymer carrier,micelles carring progesterone were assembled in water.The drug load and encapsulation ratio under different conditions were investigated and the optimal proportion was selected for the in vitro release study.The results show that the micelles can carry progesterone with a drug load of 4.26%and the encapsulation efficiency of 21.30%.The nano micelles can effectively prolong the release of progesterone.This research is an experimental and technical reference for the development of similar dosage forms of steroid hormones.

关 键 词：聚合物 聚乙二醇-聚丙烯基缩水甘油醚 黄体酮 胶束 

分 类 号：O631[理学—高分子化学]