鲎血源主要生物活性物质功能研究进展  

Research progress on major bioactive substances from hemolymph of horseshoe crab

作　　者：刘喜梅 江凌锋 王有基[1,2,3] 宋洁 何锦锋 台宗光 朱全刚 胡梦红 LIU Xi-mei;JIANG Ling-feng;WANG You-ji;SONG Jie;HE Jin-feng;TAI Zong-guang;ZHU Quan-gang;HU Meng-hong(National Demonstration Center for Experimental Fisheries Science Education,Shanghai Ocean University,Shanghai 201306;Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources,Ministry of Education,Shanghai Ocean University,Shanghai 201306;Shanghai Engineering Research Center of Aquaculture,Shanghai Ocean University,Shanghai 201306,China;Tianjin Era Biology Technology Co.,Ltd.,Tianjin 300457,China;Beihai Product Quality Testing Institute,Guangxi Beihai 536000,China;Shanghai Skin Disease Hospital,Tongji University School of Medicine,Shanghai 200443,China)

机构地区：[1]上海海洋大学水产科学国家级实验教学示范中心,上海201306 [2]上海海洋大学水产种质资源发掘与利用教育部重点实验室,上海201306 [3]上海海洋大学上海水产养殖工程技术研究中心,上海201306 [4]天津市一瑞生物工程有限公司,天津300457 [5]北海市产品质量检验所,广西北海536000 [6]上海市皮肤病医院,上海200443

出　　处：《中国海洋药物》2020年第5期82-88,共7页Chinese Journal of Marine Drugs

基　　金：2017北海市“十三五”海洋经济创新发展示范项目“鲎试剂及中华鲎生态利用产业链协同创新项目”(Bhsfs006)资助。

摘　　要：鲎血阿米巴细胞大小颗粒中存在多种生物活性物质,在这些物质中,抗脂多糖因子、鲎素抗菌肽、鲎防御素和D因子等是鲎先天免疫系统中的重要功能物质。体外研究表明,它们对细菌、真菌、病毒等有强烈的抑制作用,而对正常细胞毒性较低,是开发肽类抗菌药的重要候选物质。本文主要介绍存在于阿米巴细胞中的鲎源抗菌物质,对其结构、功能、作用机理以及基因工程重组鲎素的研究进展进行综述,并对鲎源抗菌肽的发展趋势进行讨论。The amebocyte of horseshoe crab contains various bioactive substances,among these substances,anti-LPS factor,Tachyplesins,Big defensin,factor D,etc,play an important role in immunological function in the limulus immune system.In vitro researches showed that they have a strong inhibitory effect against bacteria,fungi and some viruses,while have low toxicity to normal cells.Therefore,these antimicrobial peptides or proteins are important candidates for the development of peptide drugs.This paper introduces the species of antimicrobial substances in amebocyte of horseshoe crab and their structure,function,action mechanism as well as the research progress on recombinant tachyplesins.Meanwhile,the development trend of antimicrobial peptides of horseshoe crab was discussed.

关 键 词：阿米巴细胞 抗菌肽 生物活性 重组鲎素 

分 类 号：R913.77[医药卫生—药学]