噻虫嗪绿色合成新工艺  

New synthesis process of thiamethoxam

作　　者：史三冬 张英[2] 宋建华 柳海营 刘亚南 赤国彤 SHI Sandong;ZHANG Ying;SONG Jianhua;LIU Haiying;LIU Yanan;CHI Guotong(Hebei Derui Chemicals Co.,Ltd.,Shijiazhuang 050000,China;Hebei Chemical&Pharmaceutical College,Shijiazhuang 050000,China)

机构地区：[1]河北德瑞化工有限公司,河北石家庄050000 [2]河北化工医药职业技术学院,河北石家庄050000

出　　处：《世界农药》2020年第11期42-44,共3页World Pesticide

摘　　要：为了提高收率,降低成本,减少污染,以1-异硫氰酸基-2-氯-2-丙烯为原料,氯气为氯化剂,经氯化环化、脱气、脱溶、减压精馏得到噻虫嗪中间体2-氯-5-氯甲基噻唑,总收率为87.5%,含量为98.9%。与硫酰氯为氯化剂的工艺相比,该路线操作方便,经济效益高,易于工业化生产。In order to improve the yield,reduce the cost and the pollution,2-chloro-5-chloromethylthiazole was synthesized by chlorination cyclization,degassing,desolvation and vacuum distillation with 1-isothiocyanate-2-chloro-2-propene as raw material and chlorine as chlorinating agent.The total yield is 87.5%and the content is 98.9%.Compared with the process of using thiochloride as chlorinating agent,this route is more convenient to operate,more economical and thus suitable for industrialization.

关 键 词：噻虫嗪 2-氯-5-氯甲基噻唑 氯气 合成 

分 类 号：TQ450[化学工程—农药化工]