结合病例与文献分析碳青霉烯类抗菌药物对儿童丙戊酸钠血药浓度的影响  

Clinical Analysis and Literature Review of Effects of Carbapenems Antibiotics on Blood Concentration of Sodium Valproate in Children

作　　者：王霞 黄建权[1] Wang Xia;Huang Jianquan(Shanghai Children’s Hospital,Children’s Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200062,China;Tai’an City Central Hospital,Shandong Tai’an 271000,China)

机构地区：[1]上海市儿童医院,上海交通大学附属儿童医院,上海200062 [2]泰安市中心医院,山东泰安271000

出　　处：《儿科药学杂志》2020年第11期35-38,共4页Journal of Pediatric Pharmacy

基　　金：上海市卫生计生系统重要薄弱学科建设计划项目,编号2016ZB0305-01。

摘　　要：目的:探讨碳青霉烯类抗菌药物与丙戊酸钠在儿童应用中的相互作用特点。方法:从1例癫痫患儿外科手术后应用美罗培南导致丙戊酸钠血药浓度降低的案例出发,查阅CNKI及PubMed等数据库,对已有的儿童患者应用碳青霉烯和丙戊酸钠相互作用的文献进行回顾性分析。结果:已有文献报道中,服用丙戊酸钠的患儿使用美罗培南后,丙戊酸钠的血药浓度明显下降。结论:国内外均不推荐碳青霉烯类抗菌药物和丙戊酸钠同时使用,但实际工作中,二者同时使用的情况仍时有发生。儿科临床药师需加强药学监护,提高碳青霉烯类抗菌药物与丙戊酸钠具有相互作用的临床认知,制定应对措施,促进合理用药。Objective:To probe into the interaction characteristics of carbapenem antibiotics and sodium valproate in children.Methods:Based on the case of a child with epilepsy whose blood drug concentration of valproate was decreased due to the application of meropenem after surgery,CNKI and PubMed were retrieved,and literature related to the interaction between carbapenem and valproate in children was retrospectively analyzed.Results:Related literature indicated that the blood concentration of valproate decreased significantly after the use of meropenem in children taking valproate.Conclusion:The drug combination of carbapenem and sodium valproate is not recommended at home and abroad,but in clinical practice,the use of both still occurs.Pediatric clinical pharmacists need to strengthen pharmaceutical care,improve the clinical awareness of interaction between carbapenem and sodium valproate,formulate the countermeasures to promote the rational drug use.

关 键 词：丙戊酸钠 碳青霉烯 药物相互作用 儿科 血药浓度 

分 类 号：R969.3[医药卫生—药理学]