磁共振纳米探针用于阿尔茨海默病的靶向成像诊断  

Nanoprobes for Alzheimer’s disease-targeted magnetic resonance imaging diagnosis

作　　者：章宏传 翟建[1] ZHANG Hongchuan;ZHAI Jian(Department of Radiology,Yijishan Hospital,Wannan Medical College,Wuhu 241001,China)

机构地区：[1]皖南医学院弋矶山医院医学影像中心,安徽芜湖241001

出　　处：《沈阳医学院学报》2020年第6期591-595,共5页Journal of Shenyang Medical College

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病之一,淀粉样斑块和神经元纤维缠结是AD最重要的两种病理改变。磁共振成像(MRI)是早期、准确诊断具有行为改变和认知障碍等临床症状AD的有效非侵入性方法。本文旨在对AD靶向的MRI纳米探针的最新研究进展进行介绍,提出了纳米探针用于AD的MRI诊断的未来方向——增强探针的性能、降低探针的毒性以及开发AD靶向诊疗一体化纳米探针。Alzheimer disease(AD)is one of the most common neurodegenerative diseases,amyloid plaques and neurofibrillary tangles are the two most important pathological changes in AD.Magnetic resonance imaging(MRI)is an effective non-invasive method for early and accurate diagnosis of AD with clinical symptoms such as behavioral changes and cognitive impairment.This review aims to introduce the latest research progress of AD-targeted MRI nanoprobes.Finally,we propose the future direction of nanoprobes for MRI diagnosis of AD:enhancing nanoprobe performance,reducing nanoprobe toxicity,and developing theranostic nanoprobes.

关 键 词：阿尔茨海默病 淀粉样斑块 神经元纤维缠结 磁共振成像 纳米探针 诊疗一体化 

分 类 号：R445.2[医药卫生—影像医学与核医学]