无铜参与的钯催化Sonogashira偶联反应合成β-(2-苯乙炔基)环丁酮类化合物  

Cu-free palladium-catalyzed Sonogashira coupling for the synthesis of β-(2-alkynylaryl)cyclobutanones

作　　者：钱艳艳 高继强 武原琪 张敏[1] 朱俊杰 刘宇[1] QIAN Yan-yan;GAO Ji-qiang;WU Yuan-qi;ZHANG Min;ZHU Jun-jie;LIU Yu(Advanced Institute of Materials Science,College of Chemistry and Life Science,Changchun University of Technology,Changchun 130012,China)

机构地区：[1]长春工业大学化学与生命科学院材料科学高等研究院,吉林长春130012

出　　处：《分子科学学报》2020年第5期368-375,I0002,共9页Journal of Molecular Science

基　　金：国家自然科学基金资助项目(21602015);吉林省教育厅“十三五”科学技术项目(JJKH20181022KJ)。

摘　　要：本文发展了一种简单高效的单钯催化体系,用于β-(2-溴芳基)环丁酮和末端炔的Sonogashira反应中,合成了一系列邻炔芳基-β-环丁酮类化合物.反应条件简单温和,催化剂及配体稳定易得,实验操作简捷便利,底物普适性良好.实现了金催化剂引发的该环丁酮类化合物的扩环反应.We disclose herein a simple and efficient single-palladium-catalyzed Sonogashira coupling reaction towards β-(2-alkynylaryl)cyclobutanones. The reaction is featured by its high efficiency, simple and mild reaction conditions, stable and accessible catalyst and broad substrate scope. Initial exploration showed that Au-catalyzed ring-expansion reactions of the obtained cyclobutanone derivatives lead to naphthalenone products.

关 键 词：钯催化 Sonogashira偶联 β-邻炔苯基环丁酮 萘酮 

分 类 号：O624[理学—有机化学]