补气方联合肠内营养对胃癌患者术后免疫功能和肠道功能的影响  

Effect of Buqi Recipe Combined with Enteral Nutrition on Postoperative Immune Function and Intestinal Function of Patients with Gastric Cancer

作　　者：高雪 李岩[2] 汪楠[1] GAO Xue;LI Yan;WANG Nan(GCP Office,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032 Liaoning,China;Dept.of Spiern and Stomach,Affiliated Hospital of Liaoning Iniversity of Traditional Chinese Medicine,Shenyang 110032 Liaoning,China)

机构地区：[1]辽宁中医药大学附属医院GCP办公室,辽宁沈阳110032 [2]辽宁中医药大学附属医院脾胃科,辽宁沈阳110032

出　　处：《广州中医药大学学报》2020年第11期2103-2108,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(编号:81173154)。

摘　　要：【目的】探讨补气方联合肠内营养对胃癌患者术后机体免疫功能和肠道功能的影响。【方法】将96例接受根治性手术的胃癌患者随机分为研究组和对照组,每组各48例。对照组患者接受肠内营养支持及优质护理干预,研究组在对照组基础上给予补气方治疗,疗程为7 d。比较2组患者治疗前后T细胞亚群(CD3+、CD4+及CD4+/CD8+)、炎性因子[C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]水平和营养指标[血浆总蛋白(TP)、前清蛋白(PA)、白蛋白(ALB)、转铁蛋白(TF)]的变化情况,观察2组患者胃肠功能恢复及并发症发生情况。【结果】(1)T细胞亚群方面:治疗后,2组患者CD3+、CD4+及CD4+/CD8+值均较治疗前明显升高(P<0.05),且研究组治疗后的CD3+、CD4+及CD4+/CD8+值均明显高于对照组(P<0.05)。(2)炎性因子方面:治疗后,2组患者术后升高的IL-6、TNF-α、CRP水平仍未恢复至治疗前水平(P<0.05),但研究组治疗后的IL-6、TNF-α、CRP水平均明显低于对照组(P<0.05)。(3)营养指标方面:治疗后,2组患者的ALB、TP、TF水平均较治疗前明显升高,PA水平均较治疗前明显下降(P<0.05);组间比较,研究组治疗后的ALB、PA、TP、TF水平均明显高于对照组(P<0.05)。(4)胃肠功能恢复情况:治疗后,研究组患者的排气、排便和肠鸣音复常时间及胃管留置时间均较对照组明显缩短,胃管总引流量均较对照组明显减少(P<0.05或P<0.01)。(5)并发症方面:研究组的并发症发生率为6.25%(3/48),明显低于对照组的20.83%(10/48),差异有统计学意义(P<0.05)。【结论】补气方联合肠内营养能有效提高胃癌患者术后机体免疫功能,改善患者营养状况,促进患者胃肠功能恢复,并且有利于减少患者的并发症发生率。Objective To investigate the effect of Buqi Recipe combined with enteral nutrition on postoperative immune function and intestinal function of patients with gastric cancer.Methods Ninety-six patients with gastric cancer after radical operation were divided into trial group and control group,48 cases in each group.The two groups received enteral nutrition support and high-quality nursing intervention,and additionally the trial group was given oral use of Buqi Recipe for 7 days of continuous treatment.Before and after treatment,the levels of T cell subsets(CD3^+,CD4^+and CD4^+/CD8^+),inflammatory factors of C-reactive protein(CRP),interleukin 6(IL-6),and tumor necrosis factor alpha(TNF-α),and the nutritional indicators of plasma total protein(TP),prealbumin(PA),albumin(ALB),and transferrin(TF)in the two groups were observed.And the gastrointestinal function recovery and the incidence of the complications were also compared between the two groups.Results(1)After treatment,the levels of CD3+,CD4+and CD4+/CD8+in the two groups were obviously increased in comparison with those before treatment(P<0.05),and the trial group had higher post-treatment levels of CD3+,CD4+and CD4+/CD8+than the control group(P<0.05).(2)After treatment,the levels of IL-6,TNF-α,and CRP in the two groups still did not recover to those before treatment(P<0.05),but the levels of IL-6,TNF-αand CRP in the trial group were all lower than those in the control group(P<0.05).(3)After treatment,the levels of ALB,TP and TF in the two groups were obviously increased and PA was obviously decreased in comparison with those before treatment(P<0.05).The intergroup comparison showed that the post-treatment levels of ALB,PA,TP,and TF in the trial group were higher than those in the control group(P<0.05).(4)After treatment,time for the recovery of anal exhaust,defecation,and bowel sound,and time for the indwelling of gastric tube were obviously shortened,and the total gastric tube drainage volume was reduced in the trial group in comparison with those in the co

关 键 词：胃癌 根治性手术 补气方 肠内营养 肠道功能 免疫功能 

分 类 号：R273.52[医药卫生—中西医结合]