经颅重复针刺激治疗帕金森病轻度认知障碍的疗效观察  

Clinical Observation on Mild Cognitive Impairment in Patients of Parkinson’s Disease Treated by Repetitive Transcranial Acupuncture Stimulation Therapy

作　　者：刘征[1,2] 梁爽[1] 毕海洋 史留举[1] 刘博文 张译文 马瑀彤 于楠楠 LIU Zheng;LIANG Shuang;BI Hai-Yang;SHI Liu-Ju;LIU Bo-Wen;ZHANG Yi-Wen;MA Yu-Tong;YU Nan-Nan(Heilongjiang University of Chinese Medicine,Harbin 150040 Heilongjiang,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040 Heilongjiang,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《广州中医药大学学报》2020年第11期2152-2156,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：黑龙江中医药大学“优秀创新人才支持计划”资助项目(编号:2018RCD10);黑龙江省博士后资助基金项目(编号:LBH-Z18247)。

摘　　要：【目的】观察经颅重复针刺激疗法治疗帕金森病轻度认知障碍的临床疗效。【方法】将60例帕金森病轻度认知障碍的患者随机分为观察组和对照组,每组各30例,观察组给予经颅重复针刺激疗法治疗,对照组给予普通针刺手法治疗,每周治疗6次,连续治疗2周。治疗2周后,观察2组患者治疗前后蒙特利尔认知评估量表(MoCA)、帕金森病生活质量量表(PDQ-39)评分的变化情况,比较2组患者治疗前后5-羟色胺(5-HT)水平的变化情况,并评价2组患者的临床疗效。【结果】(1)治疗后,2组患者的MoCA评分及PDQ-39评分均明显改善(P<0.05),且观察组在改善MoCA评分及PDQ-39评分方面均明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的5-HT水平明显改善(P<0.05),且观察组在改善5-HT水平方面均明显优于对照组,差异有统计学意义(P<0.05)。(3)观察组总有效率为86.7%(26/30),对照组为70.0%(21/30)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。【结论】经颅重复针刺激治疗帕金森病轻度认知障碍,能明显改善患者临床症状,提高患者生活质量,疗效显著。Objective To observe the curative efficacy of repetitive transcranial acupuncture stimulation therapy for the treatment of mild cognitive impairment in patients of Parkinson’s disease.Methods Sixty patients with mild cognitive impairment of Parkinson’s disease were randomly divided into observation group and control group,30 cases in each group.The observation group received repetitive transcranial acupuncture stimulation therapy,and the control group received ordinary acupuncture therapy,6 times per week,the treatment lasting 2 continuous weeks.After 2 weeks of treatment,the changes in scores of Montreal Cognitive Assessment Scale(MoCA),Parkinson’s Disease Quality of Life Scale(PDQ-39)were observed in the two groups before and after treatment,the serotonin(5-HT)level was compared in the two groups before and after treatment,and the clinical efficacy in the two groups was evaluated.Results(1)After treatment,the MoCA and PDQ-39 scores in the two groups were improved(P<0.05),and the improvement in MoCA and PDQ-39 scores of the observation group was superior to that of the control group(P<0.05).(2)After treatment,the 5-HT level in the two groups were improved(P<0.05),and the improvement in 5-HT level of the observation group was superior to that of the control group(P<0.05).(3)The total effective rate was 86.7%(26/30)in the observation group,and was 70.0%(21/30)in the control group.The curative efficacy of the observation group was superior to that of the control group(P<0.05).Conclusion Repetitive transcranial acupuncture stimulation therapy is effective for improving mild cognitive impairment in patients of Parkinson’s disease,and promoting quality of life.

关 键 词：经颅重复针刺激 帕金森病 轻度认知障碍 生活质量 疗效观察 

分 类 号：R246.9[医药卫生—针灸推拿学]