黄芩苷缓释膜应用于重度慢性牙周炎的体外抑菌效果  

Antibacterial Effects of Baicalin Sustained-Release Membranes Against Severe Chronic Periodontitis in Vitro

作　　者：陈苑[1] 景向东[1] 卢惠冰[1] CHEN Yuan;JING Xiang-Dong;LU Hui-Bing(The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学第一附属医院,广东广州510405

出　　处：《广州中医药大学学报》2020年第11期2206-2209,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局面上科研项目(编号:20172047)。

摘　　要：【目的】评估含4种质量黄芩苷的缓释膜对重度慢性牙周炎龈沟液的体外抑菌效果,为临床应用提供指导。【方法】比较含黄芩苷0.5、1.0、1.5、2.0 g的缓释膜体外降解率,参照纸片扩散法观察不同缓释膜对重度慢性牙周炎龈沟液的体外抑菌情况。【结果】黄芩苷含量与缓释膜降解率相关度较弱;4种缓释膜均抑菌,其中含黄芩苷2.0 g的缓释膜抑菌圈直径最大、7 d内直径变化最小。【结论】缓释膜降解率与黄芩苷含量无显著相关。含黄芩苷2.0 g的缓释膜抑菌作用与抑菌稳定性最优,含1.5 g的次之。Objective To evaluate the antibacterial effect of sustained-release membranes containing 4 different contents of baicalin against gingiva groove liquid flora of severe chronic periodontitis in vitro for providing clinical guidance.Methods The degradation rates of sustained-release membranes containing 0.5,1.0,1.5,and 2.0 g of baicalin were compared.The effects of the different sustained-release membranes on inhibiting bacteria in gingiva groove liquid at the bottom of periodontal pocket of severe chronic periodontitis were observed by referring to disk diffusion method.Results The correlation between contents of baicalin and degradation rates of sustained-release membranes was weaker.The sustained-release membranes containing 4 different contents of baicalin all had antibacterial effect,in which the diameter of the antibacterial ring in sustained-release membranes containing 2.0 g content of baicalin was the largest,and the changes within 7 days were the smallest.Conclusion The degradation rates of sustained-release membranes have no significant correlation with baicalin contents.The antibacterial effect of sustained-release membranes containing 2.0 g of baicalin and the stabilities of antibacterial rings were best,next 1.5 g of baicalin.

关 键 词：黄芩苷 缓释膜 重度慢性牙周炎 龈沟液 

分 类 号：R285.5[医药卫生—中药学]