基于PET动态成像的呼吸运动校正对肝脏动力学分析的影响研究  

A study on the influence of respiratory MC on liver kinetic analysis based on PET dynamic imaging

作　　者：邵韵文 王静楠[2] 王雪竹 丁海艳[1,3] 霍力[2] 张辉[1] SHAO Yun-wen;WANG Jing-nan;WANG Xue-zhu(Department of Biomedical Engineering,School of Medicine,Tsinghua University,Beijing 100084,China;不详)

机构地区：[1]清华大学医学院生物医学工程系,北京100084 [2]中国医学科学院北京协和医学院,北京协和医院核医学科,北京100730 [3]清华大学生物医学影像研究中心,北京100084

出　　处：《中国医学装备》2020年第11期8-13,共6页China Medical Equipment

基　　金：国家自然科学基金(81571713)“肝细胞癌乙酸盐PET动态显像的动力学分析及临床应用研究”;中国医学科学院基金(2016-I2M-4-003)“心肺血管病的分子影像诊断结合新型干预治疗的研究”;中国医学科学院基金(CAMS-2018-I2M-3-001)“核医学医工结合精准诊疗平台建设”。

摘　　要：目的:评估基于门控的呼吸运动校正对于正电子发射断层成像(PET)动态成像和肝脏肿瘤动力学分析的影响。方法:选取医院收治的8例肝胆癌症患者,经^(18)F-氟代脱氧葡萄糖(^(18)F-FDG)PET扫描60 min,重建27帧动态PET图像(6帧20 s、8帧60 s、5帧120 s和8帧300 s),采用呼吸门控等时间间隔划分6个时相,以呼气末期作为呼吸运动校正后图像。建立肝脏三房室代谢模型,以肝动脉和门静脉供血,计算肝脏动力学参数K1、k2、k3、k4、vB和Ki,评估呼吸运动校正前后的显著性差异。将肝脏肿瘤按发生位置分为顶部、中部及底部3类,按体积大小分为小肿瘤、大肿瘤2类,测量体积中心的三维位移量、体积以及最大和平均标准化摄取值(SUV(max)、SUV(mean)),计算各参数校正前后变化百分比,设计衡量位移与体积关系百分比(AVR)。结果:呼吸运动校正后,所有肿瘤位置的K1均显著增长,其整体均值从1.09±0.48升高至1.57±0.65,差异有统计学意义(t=8.15,P<0.05);除顶部肿瘤外,k3校正后均有显著性下降,整体由校正前0.064±0.038降至校正后0.047±0.027,其差异有统计学意义(t=6.31,P<0.05)。顶部肿瘤的位移量最大,达到(3.15±0.86)mm,SUV(max)和SUV(mean)增长最多;中部肿瘤的各参数变化与平均值接近。呼吸运动校正后,小肿瘤受位移的影响程度更大,体积增大(112.98±191.77)%,SUV升高、K1的增长和k3的降低与AVR的增长呈正相关。结论:呼吸运动对肝脏动力学分析有较大的影响,尤其对顶部肿瘤和小肿瘤。在肝脏PET动态成像中应用呼吸运动校正,可以获得更准确的动力学参数。Objective:To evaluate the effect of respiratory gated motion correction on dynamic positron emission tomography(PET)and kinetic analysis of liver tumors.Methods:Eight patients with hepatocellular carcinoma or cholangiocarcinoma went through 60-minute 18F-fluorodeoxyglucose(18F-FDG)PET scan.Data were reconstructed into 27-frame PET images(6×20s,8×60s,5×120s and 8×300s).Six gated phases were divided based on equal time intervals of each respiration,and the end-expiration phase was utilized as images with motion correction(MC).The two-tissue compartment model was built up for liver,with dual-input from hepatic artery and portal vein,to calculate kinetic parameters K1,k2,k3,k4,vB and Ki.The significance of the difference between parameters with and without motion correction(NMC)was assessed.Tumor lesions were classified into three groups by their locations:at the apex(TA),in the middle(TM)and at the bottom(TB),and also into two groups by their sizes:small and large.Body-centered motion amplitude,size,SUVmax and SUVmean were measured.The differences between MC and NMC were calculated.The relation between motion amplitude and size was measured as AVR.Results:With MC,K1 of all location groups increased significantly and the overall average K1 increased from 1.09±0.48 to 1.57±0.65(t=8.15,P<0.05);except for TA,k3 decreased significantly and the overall average k3 decreased from 0.064±0.038 to 0.047±0.027(t=6.31,P<0.05).For TA,its average motion amplitude,reaching(3.15±0.86)mm,SUVmax difference and SUVmean difference were all the largest;the aforementioned parameters of TM were close to the mean of all tumors.Small tumors were affected by motion amplitude more than bigger ones,the size increase achieved(112.98±191.77)%with MC.Besides,the overall SUV increase,the K1 increase and the k3 decrease were positively related to the increase of AVR.Conclusion:Respiratory motion brings major impacts to liver kinetic analysis,especially for tumors at the apex and small tumors.More accurate estimation of kinetic parameters c

关 键 词：正电子发射断层成像(PET)动态成像 呼吸门控 运动校正(MC) 肝脏动力学分析 肝脏肿瘤 

分 类 号：R816.5[医药卫生—放射医学]