甘草酸二胺与硫普罗宁在护肝治疗中的临床应用体会  

Clinical Application Experience of DiamineGlycyrrhizinate and Tiopronin in the Treatment of Liver Protection

作　　者：周秀红 ZHOU Xiuhong(Binhai New Renci Hospital,Yancheng,Jiangsu 224599,China)

机构地区：[1]滨海新仁慈医院,江苏盐城224599

出　　处：《大医生》2020年第14期85-87,共3页Doctor

摘　　要：目的对比分析甘草酸二胺和硫普罗宁在肝硬化、肝癌、肝肿瘤转移等疾病所致的肝功能损伤中的护肝效果。方法选取滨海新仁慈医院2017年10月至2019年2月收治的肝病患者24例作为研究对象,根据治疗方法的不同分为甘草酸二胺组、硫普罗宁组、常规组,各8例。甘草酸二胺组在常规治疗的基础上加用甘草酸二铵注射液治疗;硫普罗宁组在常规治疗基础上加用硫普罗宁注射液治疗;常规组仅单纯采用常规治疗。对比三组患者治疗前后的肝功能各项指标变化情况。结果甘草酸二胺组对肝硬化重度肝损伤患者的保肝降酶治疗效果显著高于常规组(P<0.05);硫普罗宁组对肝硬化患者的轻度肝损伤治疗效果高于常规组(P<0.05);而甘草酸二胺组和硫普罗宁组比较,差异无统计学意义(P>0.05)。结论传统药物甘草酸二胺在肝损伤的治疗中,尤其是对于肝硬化失代偿伴有丙氨酸氨基转移酶显著增高患者保肝降酶的效果显著,而硫普罗宁在肝损伤(如肿瘤放射、化学治疗等)护肝治疗中侧重于增强肝脏抗损害的能力,可用于轻度丙氨酸氨基转移酶升高的保肝治疗。Objective To compare the protective effects of diamineglycyrrhizinate and tiopronin on liver function injury caused by liver cirrhosis,liver cancer and tumor liver metastasis.Methods A total of 24 patients with liver disease admitted to Binhai New Renci Hospital from October 2017 to February 2019 were selected.According to different treatment methods,the patients were divided into diamineglycyrrhizinate group,tiopronin group and conventional group,and 8 cases in each group.The diamineglycyrrhizinate group was treated with diammoniumglycyrrhizinate injection on the routine basis.Tiopronin group was treated with tiopronin injection on the basis of conventional treatment.The conventional group received only conventional treatment.The changes of liver function indexes before and after treatment were compared among the 3 groups.Results The therapeutic effect of glycyrrhizinatediamine on liver protection and lowering enzyme in patients with severe liver injury was significantly higher than that in the conventional group(P<0.05).The therapeutic effect of tiopronin group on mild liver injury in patients with cirrhosis was higher than that in the conventional group(P<0.05).There was no significant difference between glycyrrhizinatediamine group and tiopronin group(P>0.05).Conclusion Traditional drugs glycyrrhizic acid diamine in the treatment of liver damage,especially for decompensated cirrhosis accompanied by alanine aminotransferase significantly higher in patients with liver enzyme reduction effect is remarkable,and sulfur profumoning in liver damage(such as tumor radiation and chemotherapy)protect liver treatment focuses on enhance the ability of the liver damage resistance,can be used in mildly elevated alanine aminotransferase protect liver treatment.

关 键 词：甘草酸二铵 硫普罗宁 肝硬化 肝损害 

分 类 号：R28[医药卫生—中药学]