手性膦腈碱有机催化的研究进展  

Recent Progress of Chiral Iminophosphorane Catalysis

作　　者：张艳霞 韩建伟 Zhang Yanxia;Han Jianwei(Shanghai Key Laboratory of Functional Materials Chemistry,Department of Fine Chemicals,School of Chemistry&Molecular Engineering,East China University of Science and Technology,Shanghai 200237;Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032)

机构地区：[1]华东理工大学化学与分子工程学院精细化工系,上海市功能性材料化学重点实验室,上海200237 [2]中国科学院上海有机化学研究所,沪港化学合成联合实验室,上海200032

出　　处：《有机化学》2020年第10期3154-3165,共12页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21472213,21202186);香港裘槎基金资助项目。

摘　　要：有机碱催化不对称合成是小分子催化化学的重要分支,也是手性合成领域的研究热点之一.膦腈碱化合物是有机超强碱,性质稳定,可作为一类有机强碱小分子催化剂应用于不对称催化有机反应.讨论了膦腈碱化合物在小分子催化领域的研究进展,包括膦腈碱的合成以及其在不对称反应中的应用.As organocatalysts,organic base catalysts play an important role in the quest for optically pure compounds.Chiral iminophosphoranes,being organosuperbases,are very stable under air and moisture conditions,thereby providing an attractive platform for the design of various asymmetric organocatalysts.The recent achievements concerning chiral iminophosphoranes in the development of both organocatalysis and their applications in asymmetric synthesis are summarized and discussed.

关 键 词：手性膦腈碱 不对称 研究进展 有机催化 

分 类 号：O621.251[理学—有机化学]