铜(I)促进的3-重氮吲哚-2-亚胺与AgSCF3的三氟甲硫基化反应:3-三氟甲硫基-2-氨基吲哚的合成  

Copper(I)-Promoted Trifluoromethylthiolation of 3-Diazoindolin-2-imines with AgSCF3:Synthesis of 3-((Trifluoromethyl)thio)-2-aminoindoles

作　　者：郎勃 Muhammad Suleman 吕萍[1] 王彦广[1] Lang Bo;Suleman Muhammad;Lu Ping;Wang Yanguang(Department of Chemistry,Zhejiang University,Hangzhou 310027)

机构地区：[1]浙江大学化学系,杭州310027

出　　处：《有机化学》2020年第10期3300-3306,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21772169,21632003)资助项目.

摘　　要：报道了一种通过铜(I)促进的3-重氮吲哚-2-亚胺与AgSCF3的三氟甲硫基化反应,合成3-三氟甲硫基-2-氨基吲哚类化合物的简洁、高效新方法,其主要特征包括底物范围广,铜(I)催化剂廉价,重氮原料和三氟甲硫基化试剂容易获得,反应条件温和且时间短;此外,适量的水能够促进这一反应.A facile and efficient method for the synthesis of novel 3-((trifluoromethyl)thio)-2-aminoindoles through copper(I)-promoted trifluoromethylthiolation of 3-diazoindolin-2-imines with AgSCF3 is reported.This methodology features a broad substrate scope of diazo compounds,economical copper(I)catalyst,readily available and stable diazo materials and trifluoromethylthiolating reagent,mild reaction conditions,short reaction time and water assisted higher yields.

关 键 词：重氮化合物 金属卡宾 三氟甲硫基化 铜催化 吲哚 杂环 

分 类 号：O626.13[理学—有机化学]