钯催化α-取代苄腈与支链烯丙基碳酸酯的烯丙基烷基化反应  

Palladium-Catalyzed Allylic Alkylation Reaction ofα-Substituted Benzyl Nitriles with Branched Allyl Carbonates

作　　者：张高鹏 江阳杰 丁昌华 侯雪龙[1,3] Zhang Gaopeng;Jiang Yangjie;Ding Changhua;Hou Xuelong(State Key Laboratory of Organometallic Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032;Department of Chemistry,Shanghai University,Shanghai 200032;Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032;University of Chinese Academy of Sciences,Beijing 100049)

机构地区：[1]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032 [2]上海大学化学系,上海200444 [3]中国科学院上海有机化学研究所上海-香港化学合成联合实验室,上海200032 [4]中国科学院大学,北京100049

出　　处：《有机化学》2020年第10期3399-3409,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21532010,21772215);中国科学院先导项目(No.XDB20030100);中国科学院,上海市科委和香港裘搓基金会资助项目。

摘　　要：报道了钯催化下α-取代苄腈作为亲核试剂,与支链烯丙基碳酸酯的烯丙基烷基化反应,在易得的大位阻氮杂环卡宾配体存在下,以良好的收率、区域选择性及非对映选择性得到支链烯丙基烷基化产物.Pd-catalyzed allylic alkylation reaction ofα-substituted benzyl nitriles with branched allyl carbonates in the presence of bulkier N-heterocyclic carbene ligand was reported,which provided the corresponding allylated products in good yield with high regio-and diastereo-selectivity.

关 键 词：钯 苄腈 支链烯丙基碳酸酯 烯丙基烷基化 

分 类 号：O621.251[理学—有机化学]