石家庄市区母亲孕期空气污染暴露对新生儿出生体重影响  

Impacts of maternal air pollution exposure during pregnancy on low birth weight in urban Shijiazhuang

作　　者：崔月昕 康慧 尹洁 张荣 牛玉杰 CUI Yue-xin;KANG Hui;YIN Jie(Department of Obstetrics and Gynecology,The Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei Province 050011,China;不详)

机构地区：[1]河北医科大学第四医院妇产科,石家庄050011 [2]河北医科大学临床实践教学部 [3]河北医科大学公共卫生学院劳动卫生与环境卫生学教研室 [4]河北省环境与人群健康重点实验室

出　　处：《中国公共卫生》2020年第11期1599-1603,共5页Chinese Journal of Public Health

基　　金：国家重点研发计划(2016 YFC0900604)。

摘　　要：目的初步探讨河北省石家庄市区母亲孕期空气污染物暴露对新生儿出生体重的影响。方法收集2013年8月-2017年12月间石家庄市某省级三甲医院3407名分娩孕妇及新生儿资料和每日空气污染数据,分析孕早期、孕中期、孕晚期和整个孕期不同污染物暴露对新生儿出生体重的影响。结果新生儿低出生体重发生率为9.51%;母亲年龄、文化程度、婴儿性别、出生年份是新生儿出生体重的影响因素,母亲年龄、文化程度、产次是新生儿低出生体重发生的危险因素。多元线性回归分析结果表明,不同孕期、不同污染物对新生儿出生体重的影响存在差异,孕早期空气质量指数(AQI)、PM2.5、PM10、SO2、NO2、CO、O3的平均暴露量每增加10个单位,出生体重分别降低26.6、7.2、4.4、5.7、8.1、2.8、6.0 g;孕中期PM2.5、PM10、SO2平均暴露量每增加10个单位,出生体重分别降低12.7、6.3、4.7 g;孕晚期SO2平均暴露量每增加10个单位,出生体重降低1.3 g;整个孕期PM2.5、PM10、SO2、NO2平均暴露量每增加10个单位,出生体重分别降低8.3、6.3、5.5、1.3 g。结论孕期空气污染暴露会使新生儿出生体重降低,PM2.5、PM10、SO2对低出生体重的影响更为明显,孕早期和孕中期可能是空气污染对低出生体重影响的关键期。Objective To preliminaryly explore the effect of maternal air pollution exposure in different pregnancy periods on birth weight of neonates in urban area Shijiazhuang city,Hebei province.Methods The data on 3407 pregnant women and their newborns delivered between August 2013 and December 2017 were obtained from a grade A tertiary hospital in Shijiazhuang city;the daily air pollution data during the same period were also collected.The effects of exposure to different pollutants during early pregnancy,second and trimester,and throughout pregnancy on the birth weight of the newborns were analyzed.Results Among all the newborns,the incidence rate of low birth weight(LBW)was 9.51%;the birth weight of the neonates was influenced by maternal age,education,neonates′gender and year of birth;maternal age,education,and parity were influence factors of LBW.The results of multivariate linear regression analysis showed that there were significant differences in the effect of exposure to different pollutants on neonatal birth weight during different pregnancy periods.A decrease of 26.6,7.2,4.4,5.7,8.1,2.8,and 6.0 grams in birth weight were associated with an increment of 10 unit in average levels exposure to air quality index(AQI),particulate matter less than 2.5μm in aerodynamic diameter(PM2.5),particulate matter less than 10μm in aerodynamic diameter(PM10),sulfur dioxide(SO2),nitrogen dioxide(NO2),carbon monoxide(CO),and ozone(O3)during the first trimester;a decrease of 12.7,6.3,and 4.7 grams in birth weight were associated with an increment of 10 unit in the average level of exposure to PM2.5,PM10,and SO2 during second trimester;a decrease of 1.3 grams in birth weight was associated with an increment of 10 unit in the average level of exposure to SO2 during third trimester;a decrease of 8.3,6.3,5.5,1.3 grams in birth weight were associated with an increment of 10 unit in the average level of exposure to PM2.5,PM10,SO2,NO2 during entire pregnancy,respectively.Conclusion Maternal exposure to air pollutants during pregnancy

关 键 词：低出生体重 空气污染 PM2.5 PM10 SO2 孕期 

分 类 号：R122.7[医药卫生—环境卫生学]