体外受精-胚胎移植过程中卵巢过度刺激综合征发生危险因素分析  

ANALYSIS OF RISK FACTORS OF OVARIAN HYPERSTIMULATION SYNDROME DURING IVF-ET PROCESS

作　　者：金晔[1] 安萍 张惠娟[1] 韩宝生[1] 樊桂玲[1] Jin Ye;An Ping;Zhang Huijuan(Tangshan Matemal And Child Care Hospital,Tangshan 063000,China)

机构地区：[1]河北省唐山市妇幼保健院生殖遗传科,063000

出　　处：《中国煤炭工业医学杂志》2020年第5期528-532,共5页Chinese Journal of Coal Industry Medicine

基　　金：河北省科技厅重点研发计划自筹项目(编号:172777130)。

摘　　要：目的探究体外受精-胚胎移植(IVF-ET)过程中卵巢过度刺激综合征(OHSS)发生的相关危险因素。方法回顾性分析2018年1月—2019年1月526例该院行IVF-ET的患者,均行统一卵泡期长效长方案,根据患者IVF-ET过程中是否出现OHSS分为非OHSS组(441例)、OHSS组(85例)。统计临床资料,观察并分析OHSS发生的相关危险因素。结果526例患者IVF-ET过程中85例发生OHSS,发生率为16.16%(85/526),二组在不孕年限、不孕原因、基础雌二醇、基础黄体生成素水平、促性腺激素(Gn)天数方面比较差异均无统计学意义(均P>0.05);二组在年龄、身体质量指数(BMI)、多囊卵巢综合征、基础卵泡刺激素、基础黄体生成素/卵泡刺激素值、基础窦卵泡计数、Gn总使用量、注射人绒毛膜促性腺激素(HCG)扳机日血雌二醇值、获卵数方面比较,差异均有统计学意义(均P<0.05)。IVF-ET过程中发生OHSS的独立危险因素为年龄、多囊卵巢综合征、基础卵泡刺激素、基础黄体生成素/卵泡刺激素值、基础窦卵泡计数、Gn总使用量、注射HCG扳机日血雌二醇值、获卵数(P<0.05)。结论IVF-ET过程中OHSS的发生受多种独立危险因素的干扰,临床可根据上述危险因素采取针对性的干预措施,以获得良好的妊娠结局。Objective To explore the risk factors of ovarian stimulation syndrome(OHSS)during in vitro fertilization and embryo transfer(IVF-ET).Methods Five hundred twenty six patients who underwent IVF-ET in Tangshan Matemal and Child Care Hospital from January 2018 to January 2019 were retrospectively selected.All patients were treated with unified scheme intervention.According to whether OHSS occurred during IVF-ET,patients were divided into non OHSS group(441 Cases)and OHSS group(85 cases).The related risk factors of OHSS were observed.Results The incidence of OHSS was 16.16%(85/526)in 526 patients with IVF-ET.There was no significant difference between the two groups in terms of infertility years,infertility causes,basal estradiol,basal luteinizing hormone level and GN days(P>0.05);there were no significant differences in age,BMI,polycystic ovary syndrome,basic follicle stimulating hormone,basal luteinizing hormone/follicle stimulating hormone value,basal luteinizing hormone/follicle stimulating hormone value,basal luteinizing hormone/follicle stimulating hormone value,basal luteinizing hormone level and gonadotropin(GN)in the two groups.There were significant differences in follicular count,total use of GN,estradiol level on the day of injection ofβ-hCG,and the number of oocytes obtained(P<0.05).The independent risk factors of OHSS during IVF-ET were age,polycystic ovary syndrome,basal follicle stimulating hormone,basal luteinizing hormone/follicle stimulating hormone,basal antral follicle count,total use of GN,estradiol level on the day of injection ofβ-hCG,and the number of oocytes obtained(P<0.05).Conclusion The occurrence of OHSS in IVF-ET is interfered by many independent risk factors.According to the above risk factors,targeted interventions can be taken to obtain good pregnancy outcomes.

关 键 词：体外受精-胚胎移植 卵巢过度刺激综合征 危险因素 

分 类 号：R711.75[医药卫生—妇产科学]