探讨肝动脉介入化疗栓塞术联合还原型谷胱甘肽治疗在老年晚期肝癌患者中的应用效果  

Explore the Effect of Hepatic Artery Interventional Chemoembolization Combined with Reduced Glutathione Therapy in Elderly Patients with Advanced Liver Cancer

作　　者：陆一峰[1] LU Yi-feng(Department of Interventional Radiology,the Third Affiliated Hospital of Soochow University(Changzhou First People's Hospital),Changzhou,Jiangsu Province,213003 China)

机构地区：[1]苏州大学附属第三医院(常州市第一人民医院)介入放射科,江苏常州213003

出　　处：《系统医学》2020年第21期150-152,155,共4页Systems Medicine

摘　　要：目的探究肝动脉介入化疗栓塞术(TACE)联合还原型谷胱甘肽治疗在老年晚期肝癌患者中应用效果。方法选取该院2018年1月—2020年1月收治的60例老年晚期肝癌患者,按随机数字表法分为对照组与观察组,每组30例。对照组采用常规化疗药物治疗,观察组采用TACE联合还原型谷胱甘肽治疗。对比两组临床缓解率、复发率,治疗前后肝功能指标水平及不良反应。结果观察组临床缓解率为93.33%高于对照组73.33%,复发率为6.67%低于对照组的30.00%,差异有统计学意义(χ^2=4.320、5.455,P=0.038、0.020);观察组治疗后总胆红素为(21.53±2.46)μmol/L、直接胆红素为(6.51±1.62)μmol/L、丙氨酸转氨酶为(54.90±5.17)U/L、天门冬氨酸转氨酶为(54.10±9.01)U/L均低于对照组的(39.27±4.25)μmol/L、(15.97±1.98)μmol/L、(130.65±19.80)U/L、(89.48±9.65)U/L,差异有统计学意义(t=19.787、20.254、20.275、14.678,P<0.05);观察组不良反应发生率为23.33%,对照组不良反应发生率为36.67%,差异无统计学意义(χ^2=1.270,P=0.260)。结论老年晚期肝癌患者经TACE联合还原型谷胱甘肽治疗可获得确切效果,可有效改善患者肝功能指标,降低疾病复发率,且不良反应少,药物安全性高。Objective To explore the effect of hepatic artery interventional chemoembolization(TACE)combined with reduced glutathione therapy in elderly patients with advanced liver cancer.Methods A total of 60 elderly patients with advanced liver cancer admitted to the hospital from January 2018 to January 2020 were selected and divided into two groups according to the random number table method,with 30 cases in each group.The control group was treated with conventional chemotherapy drugs,and the observation group was treated with TACE combined with reduced glutathione.The clinical remission rate,recurrence rate,liver function index levels before and after treatment and adverse reactions were compared between the two groups.Results The clinical remission rate of the observation group was 93.33%higher than that of the control group 73.33%,and the recurrence rate was 6.67%lower than that of the control group 30.00%.The difference was statistically significant(χ^2=4.320,5.455,P=0.038,0.020);After treatment,total bilirubin was(21.53±2.46)μmol/L,direct bilirubin was(6.51±1.62)μmol/L,alanine aminotransferase was(54.90±5.17)U/L,aspartate aminotransferase was(54.10±9.01)U/L,all lower than the control group's(39.27±4.25)μmol/L,(15.97±1.98)μmol/L,(130.65±19.80)U/L,(89.48±9.65)U/L,the difference was statistically significant(t=19.787,20.254,20.275,14.678,P<0.05);the incidence of adverse reactions in the observation group was 23.33%,and the incidence of adverse reactions in the control group was 36.67%.The difference was statistically significant(χ2=1.270,P=0.260).Conclusion TACE combined with reduced glutathione treatment in elderly patients with advanced liver cancer can obtain definite results,which can effectively improve the liver function indexes of patients,reduce the recurrence rate of the disease,and have fewer adverse reactions and high drug safety.

关 键 词：晚期肝癌 肝动脉介入化疗栓塞术 还原型谷胱甘肽 肝功能指标 

分 类 号：R7[医药卫生—临床医学]