氟病区农村女性体重指数与骨密度的关联及其阈值效应关系探讨  

Threshold effects of body mass index on the bone mineral density of Chinese rural women in fluorosis area

作　　者：孙仁杰 马军[2] 段雷振 朱静媛 玉崧成 黄辉 张艳丽 周郭育 王重建[5] 巴月 Sun Renjie;Ma Jun;Duan Leizhen;Zhu Jingyuan;Yu Songcheng;Huang Hui;Zhang Yanli;Zhou Guoyu;Wang Chongjian;Ba Yue(Department of Environmental Health,Environment and Health Innovation Team,School of Public Health,Zhengzhou University,Zhengzhou 450001,China;Department of Endemic Diseases,Kaifeng Municipal Center for Disease Control and Prevention,Kaifeng 475000,China;Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450001,China;Department of Nutrition and Food Hygiene,School of Public Health,Zhengzhou University,Zhengzhou 450001,China;Department of Epidemiology,School of Public Health,Zhengzhou University,Zhengzhou 450001,China)

机构地区：[1]郑州大学公共卫生学院环境卫生学教研室郑州大学公共卫生学院环境与健康创新团队,450001 [2]开封市疾病预防控制中心地方病科,475000 [3]郑州大学附属郑州中心医院,450001 [4]郑州大学公共卫生学院营养与食品卫生学教研室,450001 [5]郑州大学公共卫生学院流行病学教研室,450001

出　　处：《中华预防医学杂志》2020年第11期1295-1299,共5页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81673116);河南省自然科学基金(162300410272)。

摘　　要：采用整群抽样的方法对豫东饮水型氟病区722名女性开展一项横断面调查,以探讨氟病区女性体重指数(BMI)与骨密度的关系及阈值效应。结果显示,与BMI正常组相比,超重组和肥胖组研究对象患骨质疏松的风险分别降低了32%和69%;氟病区女性骨密度与BMI之间存在阈值效应关系,BMI为(18.0~31.2)kg/m^2时,骨密度T值与BMI呈正相关;BMI为(31.3~40.6)kg/m^2,两者无关联相关性;未观察到低至中等程度氟暴露影响成年女性骨密度。To explore the threshold effect of body mass index(BMI)on bone mineral density(BMD)in Chinese women living in the fluorosis area,we conducted a cross-sectional study and recruited 722 women in rural areas in Henan Province,China.After detection and analyses,we found that compared with the normal BMI group,the risk of osteoporosis in the overweight and obese groups were reduced by 32%and 69%,respectively.Threshold effect analysis showed that BMD was positively correlated with BMI when BMI was 16.8-31.2 kg/m^2;while when BMI was greater than 31.2 kg/m^2,the correlation reached saturation.The correlation observed between low-to-moderate fluoride exposure and BMD in rural women was not significant.

关 键 词：氟 骨密度 骨质疏松 体重指数 

分 类 号：R599.1[医药卫生—内科学] R580[医药卫生—临床医学]