高通量血液透析与血液透析滤过在慢性肾功能衰竭治疗中的应用分析  

Application analysis of high throughput hemodialysis and hemodiafiltration in the treatment of chronic renal failure

作　　者：余燕霞 马艳飞 谢鑫 颜尚英 余兆兰 Yu Yanxia;Ma Yanfei;Xie Xin;Yan Shangying;Yu Zhaolan(Department of Nephrology Hemodialysis Room,Affiliated Hospital of Southwest Medical University,Sichuan Luzhou 646000;Department of Neurology,Affiliated Hospital of Southwest Medical University,Sichuan Luzhou;Hemodialysis Room,People's Hospital of Naxi District,Luzhou City,Sichuan Luzhou)

机构地区：[1]西南医科大学附属医院肾病内科血液透析室,四川泸州646000 [2]西南医科大学附属医院神经内科,四川泸州646000 [3]泸州市纳溪区人民医院血液透析室,四川泸州646000

出　　处：《中国社区医师》2020年第33期70-71,共2页Chinese Community Doctors

摘　　要：目的:探讨高通量血液透析与血液透析滤过在慢性肾功能衰竭治疗中的应用效果。方法:选取2018年1月-2019年12月在血液透析中心治疗的慢性肾功能衰竭患者90例,随机分两组,各45例。对照组使用血液透析滤过;观察组使用高通量血液透析。比较两组临床效果。结果:观察组治疗后血尿素氮(BUN)、血肌酐(Scr)、血β_2微球蛋白(β_2-M)及甲状旁腺素(PTH)水平均明显低于对照组,而Alb清蛋白(Alb)水平明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后Na^+、K^+、Cl^-、P3^+水平均低于治疗前,Ca^(2+)水平明显高于治疗前,差异有统计学意义(P<0.05);但两组间比较,差异无统计学意义(P>0.05)。观察组并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:高通量血液透析在慢性肾功能衰竭治疗中的应用效果更佳,对β_(2-)M和PTH的滤过效果好,能明显减轻体内毒素残留,维持电解质平衡,降低并发症发生率。Objective:To explore the application effect of high throughput hemodialysis and hemodiafiltration in the treatment of chronic renal failure.Methods:From January 2018 to December 2019,90 patients with chronic renal failure who were treated in the hemodialysis center were selected and randomly divided into two groups with 45 patients in each group.The control group received hemodiafiltration.The observation group received high throughput hemodialysis.The clinical effects between the two groups were compared.Results:After treatment,blood urea nitrogen(BUN),blood creatinine(Scr),bloodβ2 microglobulin(β2-M)and parathyroid hormone(PTH)levels in the observation group were significantly lower than the control group,and Alb albumin(Alb)levels were significantly higher than the control group,with the differences were statistically significant(P<0.05).The levels of Na+,K+,Cl-,P3+in both groups after treatment were all lower than before treatment,and the levels of Ca2+were significantly higher than before treatment,with the differences were statistically significant(P<0.05).However,there was no statistically significant difference between the two groups(P>0.05).The incidence of complication in the observation group was significantly lower than the control group,with the difference was statistically significant(P<0.05).Conclusion:High throughput hemodialysis is more effective in the treatment of chronic renal failure,has better filtration effect onβ2-M and PTH,can significantly reduce the residual toxin in the body,maintain electrolyte balance,and reduce the incidence of complications.

关 键 词：慢性肾功能衰竭 高通量血液透析 血液透析滤过 应用效果 

分 类 号：R692.5[医药卫生—泌尿科学]