靶向干预CD2AP对足细胞损伤的影响  

Effect of Targeted Intervention on CD2AP in Podocyte Injury

作　　者：董凯华 刘运广[2] DONG Kai-hua;LIU Yun-guang(Graduate School of Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China;Affiliated Hospital of Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China)

机构地区：[1]右江民族医学院研究生学院,广西百色533000 [2]右江民族医学院附属医院,广西百色533000

出　　处：《河北北方学院学报（自然科学版）》2020年第12期59-63,共5页Journal of Hebei North University:Natural Science Edition

摘　　要：多种因素可以导致足细胞损伤,如感染、毒物或药物、代谢紊乱、血流动力学改变、基因突变引起足细胞相关蛋白改变、免疫相关性损伤等。在这些损伤因素作用下,足细胞可发生足突融合、去分化、脱落凋亡、发育停滞等。随着对足细胞结构和功能的深入了解,其在肾小球疾病中的作用机制越来越清晰,足细胞损伤靶向干预成为研究的新方向之一。CD2相关蛋白(CD2-associated protein,CD2AP)作为构成肾小球足细胞裂孔隔膜的成分之一,在保持肾小球滤过屏障完整性方面发挥重要作用,其表达水平或结构改变可引起足细胞一系列病理生理改变,从而出现大量蛋白尿,甚至导致肾功能衰竭进而死亡。综述了靶向干预CD2AP对足细胞损伤的影响。Podocyte injury can be caused by many factors,such as changes in podocyte proteins caused by gene mutations,infections,poisons or drugs,immu-nological injuries,hemodynamic changes,metabolic disorders,etc.Under the action of these injury factors,podocyte reactions include foot process fusion,podocyte dedifferentiation,podocyte exfoliation and apoptosis,podocyte development stagnation.With a deeper understanding of the structure and function of podocytes,the mechanism of action in glomerular disease becomes increasinglyclear and targeted intervention of podocyte injury is a new research direction.CD2AP,as one of the components of the slit diaphragm of the glomerular pod-ocyte,plays an important role in maintaining the integrity of the glomerular filtration barrier.Changes in the expression level or structure of CD2AP can cause a series of pathophysiological changes in podocytes,then leading to proteinuria and even death due to renal failure.This article reviews the effects of targeted intervention on CD2AP in podocyte injury.

关 键 词：CD2AP 裂孔隔膜 足细胞损伤 靶向治疗 

分 类 号：R692[医药卫生—泌尿科学]