成年女性患VVC与支原体、衣原体感染的关系及年龄、MBL对感染的影响  

The relationship between VVC and mycoplasma and chlamydia infections in adult females and the influence of age and MBL on infection

作　　者：祁彦萍[1] 王英[1] 杨建敏[1] QI Yan-ping;WANG Ying;YANG Jian-min(Department of Obstetrics and Gynecology,Nanyang Central Hospital,Nanyang,Henan 473000,China)

机构地区：[1]南阳市中心医院妇产科,河南南阳473000

出　　处：《热带医学杂志》2020年第9期1183-1186,共4页Journal of Tropical Medicine

摘　　要：目的探究成年女性外阴阴道假丝酵母菌病(VVC)与支原体、衣原体感染的关系,并分析年龄及白带甘露糖结合凝集素(MBL)对感染的影响。方法收集南阳市中心医院就诊的130例VVC患者(研究组)和同期入院体检的130名非VVC女性(对照组)临床资料。记录两组宫颈分泌物支原体、衣原体感染情况,分析其年龄特征;并评估白带MBL水平与VVC合并支原体、衣原体感染的关系。结果两组受试者人型支原体(Mh)、沙眼衣原体(CT)单独感染率及解脲支原体(UU)+Mh、UU+Mh+CT混合感染率比较,差异均无统计学意义(P>0.05);研究组UU单独感染率及CT+UU/Mh混合感染率均明显高于对照组(P<0.05)。两组合并VVC的年龄集中在18~30岁,年龄≥40岁者UU感染率明显高于年龄<40岁者(P<0.05),CT感染率则明显低于年龄<40岁者(P<0.05)。VVC合并UU感染者白带MBL水平明显高于VVC合并Mh、CT感染及单纯VVC者(P<0.05);而VVC合并Mh、CT感染及单纯VVC者白带MBL水平比较,差异无统计学意义(P>0.05)。经ROC曲线分析,发现白带MBL水平对VVC合并UU感染诊断价值较高(AUC=0.700,P<0.05)。结论成年女性患VVC与支原体、衣原体感染密切相关,感染有一定年龄特点,且白带MBL水平与VCC合并UU感染相关,临床应重视相关检测。Objective To investigate the relationship between vulvovaginal candidiasis(VVC) and mycoplasma and chlamydia infections in adult females,and analyze the influence of age and leucorrhea mannose-bindinglectin(MBL) on infection.Methods The clinical data of 130 patients with VVC(study group) and 130 females without VVC(control group) who were admitted to the hospital during the same period were collected.The situations of mycoplasma and chlamydia infections in both group were recorded,and age characteristics were analyzed.The relationship between the leucorrhea MBL level and mycoplasma and chlamydia infections in patients with VVC was assessed.Results There was no significant difference between the two groups in the rate of Mycoplasma hominis(Mh) or Chlamydia trachomatis(CT) single infection,the rate of Ureaplasma urealyticum(UU)+Mh or UU+Mh+CT mixed infections(P>0.05).The rates of UU single infection and CT+UU/Mh mixed infections in the study group were significantly higher than those in the control group(P<0.05).Age range of patients with VVC in the two groups was mostly between 18 and 30 years old.The UU infection rate in patients of or older than 40 years old was significantly higher than that in patients younger than 40 years old(P<0.05),while the CT infection rate was significantly lower than that in patients younger than 40 years old(P<0.05).The leucorrhea MBL levels in patients with VVC and UU infections were significantly higher than those in patients with VVC and Mh,CT infections or patients with simple VVC(P<0.05).There was no significant difference in the leucorrhea MBL level between patients with VVC and Mh,CT infections and patients with simple VVC(P>0.05).ROC curve analysis showed that the diagnostic value of leucorrhea MBL level for VVC with UU infection was high(AUC=0.700,P<0.05).Conclusion VVC was closely related to mycoplasma and chlamydia infections,with certain age characteristics.The leucorrhea MBL level was related to VCC with UU infection.Clinically,attention should be paid to relevant tests.

关 键 词：外阴阴道假丝酵母菌病 解脲支原体 人型支原体 沙眼衣原体 

分 类 号：R375.3[医药卫生—病原生物学]