RNA中6-甲基腺嘌呤修饰的研究进展  

Recent progresses in RNA 6-methyladenine research

作　　者：罗颖 郑青[1] 房师松 LUO Ying;ZHENG Qing;FANG Shi-song(College of Pharmacy,Jinan University,Guangzhou,Guangdong 510632;Shenzhen Center for Disease Control and Prevention,Shenzhen,Guangdong 518055,China)

机构地区：[1]暨南大学药学院,广东广州510632 [2]深圳市疾病控制预防中心,广东深圳518055

出　　处：《热带医学杂志》2020年第9期1254-1258,共5页Journal of Tropical Medicine

基　　金：国家自然科学基金(81871631);深圳市科技计划项目(JCYJ20170306160244540);深圳市卫生计生系统科研项目(201602002);广东省医学科研基金(A2018269)。

摘　　要：早在40年前就在细胞中发现N6-甲基腺苷(m6A)。但是,m6A修饰的功能和相关调控蛋白近几年才陆续揭晓。m6A是真核生物mRNA中最丰富的化学修饰之一,最近研究发现m6A在各种正常生物过程中发挥重要作用。现结合近年来的研究报道论述m6A在干细胞分化、肿瘤产生和病毒感染方面的生物学功能,为表观转录组学的相关研究提供参考。N6-methyladenosine(m^6 A) was found in cells as early as 40 years ago.However,the functions of m^6A modification and regulatory enzymes have been revealed in recent years.m^6A is one of the most abundant chemical modifications in eukaryotic mRNA.Recent studies have found that m^6A plays an important role in various normal biological processes.In this review,we mainly introduce the biological functions of m^6A in stem cell differentiation,tumorigenesis and viral infection,which provides reference for epitranscriptomic research.

关 键 词：RNA修饰 6-甲基腺嘌呤 干细胞 肿瘤 病毒 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]