白花蛇舌草抗炎、抗肿瘤作用研究进展  

Research Progress of Anti-inflammatory and Anti-tumor Effects of Hedyotis Diffusa Willd.

作　　者：王信[1] 马传江[1] 杨培民[1] 曹广尚[1] 郭功玲[1] 李健[1] 辛义周[1] WANG Xin;MA Chuanjiang;YANG Peimin;CAO Guangshang;GUO Gongling;LI Jian;XIN Yizhou(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Grade Three Laboratory of Traditional Chinese Medicine Preparation of State Administration of Traditional Chinese Medicine,Jinan 250011,China)

机构地区：[1]山东中医药大学附属医院,国家中医药管理局中药制剂三级实验室,济南250011

出　　处：《中国现代应用药学》2020年第19期2420-2427,共8页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(81773950);山东省中医药科技发展计划项目(2019-1057)。

摘　　要：慢性炎症与肿瘤的发生、发展、侵袭、转移等密切相关,清热解毒中药白花蛇舌草兼具抗炎、抗肿瘤作用,在临床上常用于各种炎症、肿瘤的预防与治疗。白花蛇舌草抗炎机制研究主要涉及NF-κB、MAPK、5-LOX等信号通路,抗肿瘤研究主要为抗肠癌、抗肺癌、抗肝癌、抗乳腺癌、抗胃癌等,机制涉及PI3K/AKT、TGF-β/Smad、MAPK、STAT3等信号通路,并可能通过NF-κB、MAPK、VEGF等途径在“炎-癌”转化过程中发挥重要作用。本文综述白花蛇舌草抗炎、抗肿瘤及干预“炎-癌”转化作用,为其进一步研究提供参考。Chronic inflammation is closely related to the occurrence,development,invasion and metastasis of tumors.Hedyotis diffusa Willd.has both anti-inflammatory and anti-tumor effects and is often used to prevent and treat various kinds of inflammation and tumors.The anti-inflammatory mechanism of Hedyotis diffusa Willd.is related to NF-κB,MAPK,5-LOX and other signaling pathways and the anti-tumor effects include anti-colon cancer,anti-lung cancer,anti-liver cancer,anti-breast cancer,anti-gastric cancer,etc and anti-tumor mechanisms include signaling pathways such as PI3K/AKT,TGF-/Smad,MAPK,STAT3.Hedyotis diffusa Willd.plays an important role in the process of“inflammation-cancer”transformation through NF-κB,MAPK,VEGF and so on.This study provides a reference for the further research and development of the anti-inflammatory,anti-tumor properties and intervention on“inflammation-cancer”transformation of Hedyotis diffusa Willd.

关 键 词：炎-癌转化 白花蛇舌草 抗炎 抗肿瘤 

分 类 号：R285[医药卫生—中药学]