黄连总生物碱胃内漂浮缓释片处方组成的研究  

Study on the Formula Composition of Total Alkaloids of Coptis Chinensis Intragastric Floating Sustained Release Tablets

作　　者：梅紫薇 骆松梅[1] 徐艳艳[1] 朱延焱[1] 张霞燕[1] 傅军霞[1] 田伟强[1] MEI Ziwei;LUO Songmei;XU Yanyan;ZHU Yanyan;ZHANG Xiayan;FU Junxia;TIAN Weiqiang(Lishui Municipal Central Hospital,Lishui 323000,China)

机构地区：[1]丽水市中心医院,浙江丽水323000

出　　处：《中国现代应用药学》2020年第20期2476-2480,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省中医药科技计划项目(2019ZQ047,2013ZB148);丽水市科技计划项目(2016GYX40)。

摘　　要：目的研究黄连总生物碱胃内漂浮缓释片的处方组成及影响因素。方法以体外释放度为指标,筛选黄连总生物碱胃内漂浮缓释片的处方组成。采用单因素试验法,考察处方中羟丙甲纤维素(hydroxypropy1 methylcellulose,HPMC)、海藻酸钠、碳酸氢钠3个因素对其体外释放度的影响。结果黄连总生物碱胃内漂浮缓释片较优的处方组成为HPMC13.4%,海藻酸钠26.6%,硬脂酸镁5.4%,硬脂酸42.0%,碳酸氢钠10.6%,HPMC与碳酸氢钠的用量显著影响黄连总生物碱胃内漂浮缓释片的体外释放度。结论HPMC与海藻酸钠以1:2配伍使用作为片剂亲水凝胶骨架时,其体外释放度良好,且两者具有交互作用。OBJECTIVE To study the prescription composition and influencing factors of total alkaloids of Coptis chinensis intragastric floating sustained release tablets.METHODS The in vitro release of total alkaloids from Coptis chinensis was used as an index to screen the prescription composition of the sustained release tablets.The effects of hydroxypropyl methylcellulose(HPMC),sodium alginate and sodium bicarbonate on the in vitro release of the tablets were investigated by single factor test.RESULTS The optimal formulation of total alkaloids of Coptis chinensis intragastric floating sustained release tablets was HPMC 13.4%,sodium alginate 26.6%,magnesium stearate 5.4%,stearic acid 42.0%,NaHCO310.6%.The dosage of HPMC and sodium bicarbonate significantly affected the in vitro release of total alkaloids of Coptis chinensis intragastric floating sustained release tablets.CONCLUSION HPMC and sodium alginate combined with the ratio of 1∶2 as tablet hydrophilic gel skeleton have good release in vitro,and they interact with each other.

关 键 词：黄连总生物碱 胃内漂浮 体外释放 

分 类 号：R943[医药卫生—药剂学]