吸入用乙酰半胱氨酸联合吸入布地奈德在低肺功能肺癌患者手术前后的应用效果  

Application effect of Acetylcysteine for inhalation combined with Budesonide for inhalation in lung cancer patients with lower pulmonary function before and after surgery

作　　者：欧阳志成 刘平香 董利民[1] OUYANG Zhi-cheng;LIU Ping-xiang;DONG Li-min(Department of Respiratory Medicine,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang337000,China)

机构地区：[1]江西省萍乡市人民医院呼吸内科,江西萍乡337000

出　　处：《中国当代医药》2020年第32期52-54,共3页China Modern Medicine

基　　金：江西省萍乡市科技计划项目(2018py048)。

摘　　要：目的探讨吸入用乙酰半胱氨酸联合布地奈德在低肺功能肺癌患者手术前后的应用效果。方法选取2018年1月~2019年12月萍乡市人民医院收治的40例低肺功能肺癌患者,按照随机数字表法分为两组,每组各20例。对照组雾化吸入布地奈德,实验组加用吸入乙酰半胱氨酸。比较两组的肺功能[第1秒用力呼气容积(FEV1)、第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)、每分钟最大通气量(MVV)]、血气分析指标[动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)]、住院天数、抗生素使用强度与使用天数及并发症发生情况。结果实验组出院1个月的FEV1、FEV1/FVC水平均高于对照组,差异有统计学意义(P<0.05);实验组出院1个月的PaO2水平高于对照组,PaCO2水平低于对照组,住院天数、抗生素使用天数短于对照组,且抗生素使用强度低于对照组,差异均有统计学意义(P<0.05);两组的并发症发生率比较,差异无统计学意义(P>0.05)。结论低肺功能肺癌患者手术前后用吸入用乙酰半胱氨酸联合布地奈德治疗可改善肺功能、血气分析指标,缩短住院时间,减少抗生素使用,安全性高,值得临床应用推广。Objective To investigate the application effect of Acetylcysteine for inhalation combined with Budesonide for inhalation in lung cancer patients with lower pulmonary function before and after surgery.Methods A total of 40 lung cancer patients with lower pulmonary function who admitted in Pingxiang People′s Hospital from January 2018 to December 2019 were selected and divided into two groups according to random number table,20 cases in each group.The control group was given Budesonide for inhalation,and experimental group added Acetylcysteine.The pulmonary function(forced expiratory volume in first second[FEV1],forced expiratory volume in first second/forced vital capacity[FEV1/FVC],minute ventilation volume[MVV]),indexes of blood gas analysis(arterial partial pressure of oxygen[PaO2],arterial partial pressure of carbon dioxide[PaCO2]),hospital stays,use intensity and usage days of antibiotics,and complications were compared between two groups.Results The levels of FEV1 and FEV1/FVC in experimental group were higher than those in control group after discharge for 1 month(P<0.05).The level of PaO2 in experimental group was higher than that in control group after discharge for 1 month,the level of PaCO2 in experimental group was lower than that in control group,the hospital stays and usage days of antibiotics in experimental group were shorter than those in control group,and the use intensity of antibiotics in experimental group was lower than that in control group,the differences were statistically significant(P<0.05).There was no statistical difference in the incidence of complications between two groups(P>0.05).Conclusion Acetylcysteine inhalation combined with Budesonide inhalation in lung cancer patients with lower pulmonary function before and after surgery can improve pulmonary function and indexes of blood gas analysis,shorten hospital stays,and reduce the use of antibiotics,which has high safety and is worthy of clinical promotion.

关 键 词：低肺功能肺癌 布地奈德 乙酰半胱氨酸 

分 类 号：R563.1[医药卫生—呼吸系统]