药物共晶口服递送技术研究进展  

Advances in oral delivery technology of drug cocrystals

作　　者：冯育苗 刘梅[3] 黄碧瑶 杨美燕 FENG Yu-miao;LIU Mei;HUANG Bi-yao;YANG Mei-yan(Pharmaceutical College,Henan University,Kaifeng 475000,China;Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China;Patent Examination Cooperation Center,SIPO,Beijing 100160,China;School of Pharmaceutical Sciences,Wuhan University,Wuhan 430072,China)

机构地区：[1]河南大学药学院,开封475000 [2]军事科学院军事医学研究院毒物药物研究所,北京100850 [3]国家知识产权局专利局专利审查协作北京中心,北京100160 [4]武汉大学药学院,武汉430072

出　　处：《中国新药杂志》2020年第20期2303-2308,共6页Chinese Journal of New Drugs

基　　金：国家“重大新药创制”科技重大专项资助项目:应急药物特种制剂创新及产业化关键技术平台(2018ZX09711003-008-001)。

摘　　要：提高难溶性药物口服递送的生物利用度一直以来都是药学研究的难点和挑战。基于晶体工程学理论的药物共晶能够在不改变药物化学结构的基础上改善药物的稳定性、溶解度以及生物利用度,因而受到越来越多的关注。本文综述了近年来口服药物共晶的制备和表征方法、共晶口服吸收的影响因素、体内外相关性等最新进展。Improving the oral bioavailability of poorly water-soluble drugs has always been a challenge in pharmaceutical research. The solubility, permeability and bioavailability of the drug could be improved through the non-covalent bonding between the drug and the cocrystals conformer without changing the chemical structure of the drug. Therefore, the drug cocrystals have attracted increasing attention in recent years. The recent progress in the preparation, characterization, influencing factors of in vivo absorption and in vitro-in vivo correlation of drug cocrystals was reviewed in this article.

关 键 词：药物共晶 口服递送 难溶性药物 生物利用度 

分 类 号：R944.9[医药卫生—药剂学]