抗结核杆菌天然小分子的研究进展  

Advances in research on anti-tuberculosis natural small molecules

作　　者：王仁凤 安婷婷 蒋昌河 周蕾 杨再昌[1] WANG Ren-feng;AN Ting-ting;JIANG Chang-he;ZHOU Lei;YANG Zai-chang(College of Pharmacy,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州大学药学院,贵阳550025

出　　处：《中国新药杂志》2020年第20期2331-2340,共10页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(81760629)。

摘　　要：结核病是由结核分枝杆菌引起的慢性传染性疾病,其致死率仅次于艾滋病,近年来由于耐药性结核杆菌以及结核病与艾滋病双重感染的出现,使得结核病的治疗更加困难,对新型抗结核药物的研究更加迫切。天然产物是新药的重要来源,从中得到具有抗结核杆菌活性天然小分子的结构具有多样性,对结核病的研究和治疗具有重要意义。本文综述了近年来抗结核杆菌天然小分子的抗菌机制、结构修饰与合成以及最低抑制浓度(MIC)值低于10μg·mL^-1天然小分子的研究进展。Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, with mortality rate second only to AIDS. It has become more difficult to treat tuberculosis and the research on novel anti-tuberculosis drugs is more urgently needed due to the emergence of drug-resistant Mycobacterium tuberculosis and the dual infection of tuberculosis and AIDS in recent years. Natural products are an important source of new drugs, from which the natural small molecules with anti-Mycobacterium tuberculosis activity obtained have structural diversity, and are of great importance to the research and treatment of tuberculosis. The mechanism, structural modifications and synthesis of anti-Mycobacterium tuberculosis natural small molecules, and the progresses of research on natural small molecules with MIC values below 10 μg·mL^-1 were reviewed in this paper.

关 键 词：结核杆菌 天然小分子 结构修饰 抗菌机制 最低抑制浓度 

分 类 号：R978.3[医药卫生—药品]