活性维生素D在糖尿病肾病发病机制中的作用和治疗进展  

Progress of active vitamin D in pathogenesis and treatment of diabetic nephropathy

作　　者：董杨[1] 汪年松[1] DONG Yang;WANG Nian-song(Department of Nephrology,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院肾内科,上海200233

出　　处：《世界临床药物》2020年第10期770-775,共6页World Clinical Drug

基　　金：国家自然基金面上项目(81670657,81870504,81870468);上海交通大学医学院“临床专职科研队伍”人才计划(20192833);上海市徐汇区重点课题(SHXH201648);上海市卫计委课题(2019SY018)。

摘　　要：活性维生素D(vitamin D,VD)被认为具有多种生物活性,近年来其在防治糖尿病肾病(diabetic nephropathy,DN)方面的潜力引起了人们的特别关注。动物试验和临床研究均证明VD水平与DN发生风险呈负相关,补充活性VD已被证明可改善内皮细胞损伤,降低蛋白尿水平,减轻肾纤维化,并可延缓DN的进展。本文简要综述活性VD在DN发病机制中的可能作用,及其在DN治疗方面的新进展。Active vitamin D is considered to have a variety of biological activities.In recent years,its potential in the prevention and treatment of diabetic nephropathy (DN) has attracted special attention.Both animal studies and clinical trials have demonstrated an inverse correlation between low vitamin D levels and DN risk,and supplementation with vitamin D or its active derivatives has been verified to improve endothelial cell injury,reduce proteinuria,attenuate renal fibrosis,and resultantly delay DN progression.This review summarized new advances in the role of active vitamin D in the pathogenesis of DN and DN management.

关 键 词：糖尿病肾病 活性维生素D 治疗进展 

分 类 号：R692[医药卫生—泌尿科学] R977.24[医药卫生—外科学]