布地奈德与阿奇霉素联合特布他林治疗急性小儿支气管炎的临床疗效及其对T淋巴细胞亚群的影响  

Clinical efficacy of budesonide and azithromycin combined with terbutaline in the treatment of acute bronchitis in children and its influence on T lymphocyte subsets

作　　者：边朋 何兴宇 杨丽炜 马建利 黄东华[1] BIAN Peng;HE Xing-yu;YANG Li-wei(Newborn Pediatrics,Jizhong Energy Fengfeng General Hospital,Handan 056201,China)

机构地区：[1]冀中能源峰峰集团总医院新生儿科,河北省邯郸市056201

出　　处：《临床合理用药杂志》2020年第27期25-28,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：河北省科技厅科技攻关项目(20140529)。

摘　　要：目的探讨布地奈德与阿奇霉素联合特布他林治疗急性小儿支气管炎的临床疗效及其对T淋巴细胞亚群的影响。方法选取冀中能源峰峰集团总医院2014—2016年收治的急性支气管炎患儿86例,随机分为对照组41例和观察组45例。所有患儿入院后均给予对症治疗,对照组给予阿奇霉素^+特布他林治疗,观察组在对照组基础上给予布地奈德雾化吸入治疗。比较2组临床疗效、体温升高、咳嗽、肺部干湿啰音及呕吐等症状消失时间及住院时间。比较2组治疗前后肺功能指标,包括第一秒用力呼气容积(FEV1)、呼气峰值流速(PEF)及MEF50;T淋巴细胞亚群,包括CD3^+细胞分数、CD4^+细胞分数及CD4^+/CD8^+细胞比值;并比较2组不良反应发生率。结果观察组体温升高、咳嗽、肺部干湿啰音及呕吐等症状消失时间,住院时间短于对照组(P<0.05)。治疗前2组FEV1、PEF及MEF50比较,差异无统计学意义(P>0.05);治疗10 d后观察组FEV1、PEF及MEF50高于对照组(P<0.05)。治疗前2组CD3^+细胞分数、CD4^+细胞分数及CD4^+/CD8^+细胞比值比较,差异无统计学意义(P>0.05);治疗10 d后观察组CD3^+细胞分数、CD4^+细胞分数及CD4^+/CD8^+细胞比值高于对照组(P<0.05)。观察组总有效率高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论布地奈德与阿奇霉素联合特布他林治疗急性小儿支气管炎的临床疗效确切,可有效改善症状及肺功能,并增强免疫功能,且安全性较高。Objective To investigate the clinical efficacy of budesonide and azithromycin combined with terbutaline in the treatment of acute bronchitis in children and its influence on T lymphocyte subsets.Methods A total of 86 children with acute bronchitis were selected from 2014 to 2016 in Jizhong Energy Fengfeng General Hospital,which were selected and randomly divided into control group(41 cases)and observation group(45 cases).All children were given symptomatic treatment after admission,the control group was given azithromycin^+terbutaline treatment,and the observation group was given budesonide atomization inhalation treatment on the basis of the control group.The clinical efficacy,temperature rise,cough,lung dry and wet rales,vomiting and other symptoms disappeared time and hospitalization time were compared between the two groups.Pulmonary function indexes,including forced expiratory volume(FEV1),peak expiratory flow rate(PEF)and MEF50,T lymphocyte subsets,including CD3^+cell fraction,CD4^+cell fraction and CD4^+/CD8^+cell ratio,were compared between the two groups before and after treatment.The incidence rate of adverse reactions was compared between the two groups.Results The disappearance time of temperature rise,cough,lung dry and wet rales and vomiting in the observation group was shorter than the control group(P<0.05).There was no significant difference in FEV1,PEF and MEF50 between the two groups before treatment(P>0.05);after 10 days of treatment,FEV1,PEF and MEF50 in the observation group were higher than the control group(P<0.05).Before treatment,there was no significant difference in CD3^+cell fraction,CD4^+cell fraction and CD4^+/CD8^+cell ratio between the two groups(P>0.05);after 10 days of treatment,the CD3^+cell fraction,CD4^+cell fraction and CD4^+/CD8^+cell ratio in the observation group were higher than those in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adver

关 键 词：支气管炎 儿童 布地奈德 阿奇霉素 特布他林 T淋巴细胞亚群 治疗结果 

分 类 号：R725.6[医药卫生—儿科]