不规范使用核苷(酸)类似物抗病毒治疗的慢性乙肝患者的HBV耐药基因突变情况  

Mutations of HBV Resistance Genes in Patients with Chronic Hepatitis B Irregularly Using Nucleoside(Acid)Analogue Antiviral Therapy

作　　者：张秀英[1] ZHANG Xiu-ying(Department of Laboratory Medicine,Third People's Hospital of Changzhou City,Changzhou,Jiangsu Province,213001 China)

机构地区：[1]江苏省常州市第三人民医院检验科,江苏常州213001

出　　处：《世界复合医学》2020年第11期4-7,共4页World Journal of Complex Medicine

摘　　要：目的分析不规范使用核苷(酸)类似物抗病毒治疗的慢性乙肝患者的HBV耐药基因突变情况,为临床疾病治疗提供条件。方法60例慢性乙肝患者均在2016年1月—2018年12月期间入该院接受治疗,对患者进行HBV耐药基因突变测试,分析HBV耐药基因突变特征,明确规范使用核苷(酸)类似物治疗的价值。结果突变率分析,总发生率为70.00%,比例较高,而不同突变形式分析,发现主要突变形式主要包括M2041、M204V、N236T+M204V、L180M+M204V,发生率分别为16.67%、18.33%、21.67%、13.33%,分析不同基因型突变率,发现B型占据比例最高,为59.52%,其次为C型,19.05%,BC混合型发生率最低,仅为7.14%。结论慢性乙肝患者在进行疾病治疗的过程中因为不规范使用核苷(酸)类似物引发耐药性,因此在疾病治疗早期可进行HBV耐药基因突变测试,更加全面了解患者自身特征,规范使用核苷(酸)类似物抗病毒治疗,提升疾病治疗质量。Objective To analyze the HBV drug resistance gene mutations of chronic hepatitis B patients who Irregular using nucleoside(acid)analogue antiviral therapy to provide conditions for clinical disease treatment.Methods Sixty patients with chronic hepatitis B were admitted to our hospital for treatment from January 2016 to December 2018.The patients were tested for HBV drug resistance gene mutations,analyzed the characteristics of HBV drug resistance gene mutations,and clearly standardized the use of nucleosides(Acid)analogue treatment value.Results The mutation rate analysis showed that the total incidence rate was 70.00%,which was a high proportion.The analysis of different mutation forms found that the main mutation forms mainly included M2041,M204V,N236T+M204V,L180M+M204V,and the incidence rates were 16.67%,18.33%,21.67%and 13.33%,analysis of the mutation rate of different genotypes,it was found that type B accounted for the highest proportion of 59.52%,followed by type C,19.05%,and the lowest incidence of mixed BC,only 7.14%.Conclusion In patients with chronic hepatitis B,drug resistance is caused by non-standard use of nucleoside(acid)analogues during disease treatment.Therefore,HBV drug resistance gene mutation testing can be performed in the early stage of disease treatment to have a more comprehensive understanding of the patient’s own characteristics and standardization.Use nucleoside(acid)analogues for antiviral therapy to improve the quality of disease treatment.

关 键 词：不规范使用核苷(酸)类似物抗病毒治疗 慢性乙肝 HBV耐药基因突变 应用效果 

分 类 号：R446[医药卫生—诊断学]