rmh-TNF联合顺铂胸腔灌注治疗肺癌致恶性胸腔积液的疗效  

Efficacy of rmh-TNF Combined with Cisplatin Perfusion in the Treatment of Malignant Pleural Effusion Caused by Lung Cancer

作　　者：苏清炎[1] 何子纲 兰国翠[1] 姚向阳[1] SU Qing-yan;HE Zi-gang;LAN Guo-cui;YAO Xiang-yang(Department of Pulmonary,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian Province,361000 China)

机构地区：[1]厦门大学附属第一医院肺科,福建厦门361000

出　　处：《中外医疗》2020年第30期14-16,20,共4页China & Foreign Medical Treatment

摘　　要：目的分析重组改构人肿瘤坏死因子(rmh-TNF)联合顺铂胸腔灌注治疗肺癌致恶性胸腔积液的疗效及不良反应。方法方便收集2014年1月-2018年1月在该科住院治疗的96例肺癌致恶性胸腔积液患者,常规胸腔闭式引流排尽胸水后分为3组。rmh-TNF组31例采用胸腔局部注入rmh-TNF 300万U,顺铂组30例采用胸腔局部注入单药顺铂40 mg,联合组35例采用胸腔内局部注入rmh-TNF 300万U联合顺铂40 mg。观察3组的近期疗效、KPS评分改善情况及不良反应。结果rmh-TNF组、顺铂组和联合组的缓解率分别为74.2%、43.3%和94.3%,联合组高于rmh-TNF组和顺铂组,rmh-TNF组高于顺铂组,差异有统计学意义(P<0.05)。3组常见不良反应为发热、胸痛及胃肠道反应(恶心、呕吐),比较差异无统计学意义(P>0.05)。结论rmh-TNF联合顺铂胸腔灌注治疗肺癌致恶性胸腔积液可取得更加满意的疗效,不良反应轻微。Objective To analyze the curative effect and adverse reactions of recombinant human tumor necrosis factor(rmh-TNF)combined with cisplatin pleural perfusion in the treatment of malignant pleural effusion caused by lung cancer.Methods A total of 96 patients with malignant pleural effusion caused by lung cancer who were hospitalized in the department from January 2014 to January 2018 were conveniently collected.They were divided into three groups after routine closed drainage of the pleural effusion.In the rmh-TNF group,31 cases received local intrathoracic injection of 3 million U of rmh-TNF,30 cases of cisplatin group received local injection of cisplatin 40 mg into the chest,and 35 cases of the combination group received local intrathoracic injection of rmh-TNF 3 million U combined with cisplatin Platinum 40 mg.Observe the short-term efficacy,k Ps score improvement and adverse reactions of the three groups.Results The remission rates of rmh-TNF group,cisplatin group and combination group were 74.2%,43.3%and 94.3%,respectively.The combination group was higher than rmh-TNF group and cisplatin group,and the rmh-TNF group was higher than cisplatin group,and the difference was statistically significant(P<0.05).The common adverse reactions of the three groups were fever,chest pain,and gastrointestinal reactions(nausea,vomiting),and there was no statistically significant difference between the three groups(P>0.05).Conclusion The pleural infusion of rmh-TNF and cisplatin in the treatment of malignant pleural effusion caused by lung cancer can achieve a more satisfactory effect,with minor adverse reactions.

关 键 词：肺癌 恶性胸腔积液 rmh-TNF 顺铂 

分 类 号：R4[医药卫生—临床医学]